Results 81 to 90 of about 5,512 (205)

Lactylation in colorectal cancer: Unveiling novel mechanisms in metabolism, progression and therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lactate accumulation links metabolic reprogramming to epigenetic regulation via protein lactylation. Lactylation drives colorectal cancer proliferation, metastasis, immune escape and chemoresistance. Microbiota‐derived lactate shapes a tumour‐specific lactylation landscape in colorectal cancer.
Ming Liu, Weiwei Li, Yi Ji, Yanqing Chen, Guoli Wei, Jiege Huo, Tao Gui   +6 more
wiley   +1 more source

Evaluation of Poxvirus-Specific Antibody Response in Monkey Poxvirus-Negative and -Positive Cohorts

Vaccines
Objectives: Understanding the antibody response in monkeypox virus (MPXV)-infected and uninfected individuals is essential for developing next-generation MPXV vaccines.
Nannan Jia, Lin Ai, Yunping Ma, Chen Hua, Qi Shen, Chen Wang, Teng Li, Yingdan Wang, Yunyi Li, Yin Yang, Chi Zhou, Min Chen, Huanyu Wu, Xin Chen, Lu Lu, Yanqiu Zhou, Jinghe Huang, Fan Wu   +17 more
doaj   +1 more source

Mosquito‐Borne Viruses of Clinical Significance

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background Mosquito‐borne viruses represent a significant public health concern globally, with rising incidence rates leading to increased morbidity and mortality. This review aims to synthesize current knowledge regarding mosquito‐borne viruses, focusing on their geographic distribution, clinical impact, diagnostic challenges, treatment ...
Donath Damian
wiley   +1 more source

Evolutionary Analysis and Antiviral Drug Prediction of Mpox Virus

Microorganisms
The resurgence of mpox virus (MPXV) poses a significant challenge to global public health. Currently, there is a limited understanding of the evolutionary details of MPXV during its epidemics, and no specific drugs have been developed for it.
Zhong-Hao Lian, Chen-Hui Yang, Ye Qiu, Xing-Yi Ge   +3 more
doaj   +1 more source

Urine metabolomic analyses reveal metabolite disruptions in steroid hormone biosynthesis in monkeypox

iScience
Summary: Monkeypox virus (MPXV) poses a global health threat. Viral infection can alter host metabolic homeostasis, while its changes may influence disease severity and progression. The relationship between MPXV and metabolites has not been reported.
Xiaofeng Yang, Huiqin Yang, Chudan Liang, Fei Tang, Zhenyu Long, Linjin Fan, Yulong Wang, Zequn Wang, Mou Zeng, Weifang Kang, Pengfei Ye, Wendi Shi, Yuandong Zhou, Jingyan Lin, Hongxin Huang, Huijun Yan, Jian Wang, Linghua Li, Jun Qian, Linna Liu   +19 more
doaj   +1 more source

Nomenclature for Tracking of Genetic Variation of Seasonal Influenza Viruses

Influenza and Other Respiratory Viruses, Volume 20, Issue 2, February 2026.
ABSTRACT Background Genomic surveillance of human seasonal influenza viruses is an essential component of the Global Influenza Surveillance and Response system (GISRS) and informs the recommendations for the seasonal influenza vaccine composition. Phylogenetic analysis of viral genome sequences is used to identify groups of viruses sharing potential ...
Richard A. Neher, John Huddleston, Trevor Bedford, Nicola S. Lewis, Ruth Harvey, Monica Galiano, Alexander M. P. Byrne, Sarah James, Derek Smith, Marta Łuksza, Denis Ruchnewitz, Michael Laessig, Seiichiro Fujisaki, Shinji Watanabe, Hideki Hasegawa, Norman Hassell, David E. Wentworth, Rebecca Kondor, Yi Mo Deng, Clyde Dapat, Kanta Subbarao, Ian Barr   +21 more
wiley   +1 more source

Exploring the genomic basis of Mpox virus-host transmission and pathogenesis

mSphere
Mpox disease, caused by the monkeypox virus (MPXV), was recently classified as a public health emergency of international concern due to its high lethality and pandemic potential.
Brayden Young, Stephanie N. Seifert, Crystal Lawson, Heather Koehler   +3 more
doaj   +1 more source

MPXV DNA kinetics in bloodstream and other body fluids samples

Scientific Reports
AbstractSince spring 2022, the global epidemiology of the monkeypox virus (MPXV) has changed. The unprecedented increase of human clade II MPXV cases worldwide heightened concerns about this emerging zoonotic disease. We analysed the positivity rates, viral loads, infectiousness, and persistence of MPXV DNA for up to 4 months in several biological ...
Meschi S, Colavita F, Carletti F, Mazzotta V, Matusali G, Specchiarello E, Ascoli Bartoli T, Mondi A, Minosse C, Giancola ML, Pinnetti C, Valli MB, Lapa D, Mizzoni K, Sullivan DJ, Ou J, Focosi D, Girardi E, Nicastri E, Antinori A, Maggi F.   +20 more
openaire   +4 more sources

XMP‐Net: An XAI‐Based Modified Xception Model for Recognizing Monkeypox and Other Skin Diseases

BioMed Research International, Volume 2026, Issue 1, 2026.
This research introduces “XMP‐Net,” a modified Xception–based deep learning architecture constructed for the categorization of skin conditions, with a particular focus on identifying monkeypox. The study recognizes skin images of four categories: normal, chickenpox, measles, and monkeypox.
Ferdib-Al-Islam, Prithvi Biswas, Partha Protim Gharami, Md. Rahatul Islam, Saeed Mohammadi   +4 more
wiley   +1 more source

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source