Results 1 to 10 of about 602,475 (301)
Geneticin reduces mRNA stability.
PLoS ONE, 2022 Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting the ribosome plays a role in mRNA destruction. Furthermore, mRNA features, such as codon identities, which are directly probed by the ribosome, correlate with mRNA decay ...
Yavuz T Durmaz +2 more
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Nanobiotechnology-Enabled mRNA Stabilization
Pharmaceutics, 2023 mRNA technology has attracted enormous interest due to its great therapeutic potential. Strategies that can stabilize fragile mRNA molecules are crucial for their widespread applications.
He Xian +3 more
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Genetic variants associated mRNA stability in lung [PDF]
BMC Genomics, 2022 Background Expression quantitative trait loci (eQTLs) analyses have been widely used to identify genetic variants associated with gene expression levels to understand what molecular mechanisms underlie genetic traits. The resultant eQTLs might affect the
Jian-Rong Li +4 more
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TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability [PDF]
The EMBO JournalThe subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanisms that govern their localization are unknown.
Charlie Moffatt +9 more
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Role of mRNA stability during bacterial adaptation. [PDF]
PLoS ONE, 2013 Bacterial adaptation involves extensive cellular reorganization. In particular, growth rate adjustments are associated with substantial modifications of gene expression and mRNA abundance.
Clémentine Dressaire +6 more
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Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery
Pharmaceutics, 2023 Directly injecting naked or lipid nanoparticle (LNP)-encapsulated modified mRNA (modRNA) allows rapid and efficient protein expression. This non-viral technology has been used successfully in modRNA vaccines against SARS-CoV-2.
Magdalena M. Żak +7 more
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Research Advances on the Stability of mRNA Vaccines
Viruses, 2023 Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng +7 more
doaj +1 more source
Biology Open, 2020 During Drosophila and vertebrate brain development, the conserved transcription factor Prospero/Prox1 is an important regulator of the transition between proliferation and differentiation.
Tamsin J. Samuels +9 more
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Translation and mRNA Stability Control
Annual Review of Biochemistry, 2023 Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the post-transcriptional process that profoundly impact protein production in a cell. While it is widely known that ribosomes produce proteins, studies during the past decade have surprisingly revealed that ribosomes also control mRNA stability in a codon-dependent ...
Qiushuang, Wu, Ariel A, Bazzini
openaire +2 more sources
Stability of mRNA/DNA and DNA/DNA duplexes affects mRNA transcription. [PDF]
PLoS ONE, 2007 Nucleic acids, due to their structural and chemical properties, can form double-stranded secondary structures that assist the transfer of genetic information and can modulate gene expression.
Rayna I Kraeva +5 more
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