Results 211 to 220 of about 405,975 (264)

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Insights into the regulation of mRNA translation by scaffolding proteins. [PDF]

Biochem Soc Trans
Smith MR, Costa G.
europepmc   +1 more source

Ultrasound spatiotemporally enables prolonged therapeutic mRNA translation in engineered bacteria for enhanced cancer immunotherapy. [PDF]

Theranostics
Liu Z, Wang L, An J, Zhou T, Wei M, Yang G, Wu P, Yuan L.   +7 more
europepmc   +1 more source

Light-controlled genome editing by activation of Cas9-mRNA translation. [PDF]

Chem Sci
Schepers H, Dahm GC, Sumser M, Hüwel S, Rentmeister A.   +4 more
europepmc   +1 more source

Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation. [PDF]

PLoS Biol
Dian AL, Fabbri L, Moya-Plana A, Claps G, Ferreira JC, Labbé CM, Quidville V, Martineau S, Baille D, Besse L, Messaoudi C, Roy S, Raynal V, Baulande S, Rabeh WM, Robert C, Vagner S.   +16 more
europepmc   +1 more source

We ARE boosting translation: AU-rich elements for enhanced therapeutic mRNA translation. [PDF]

Mol Ther Nucleic Acids
Froechlich G, Sasso E.
europepmc   +1 more source

Exploiting the SunTag system to study the developmental regulation of mRNA translation

Pizzey A, Sutcliffe C, Love JC, Akabuogu E, Rattray M, Ashe MP, Ashe HL.   +6 more
europepmc   +1 more source

Codon-dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins

Harris Snell P, Naeli P, Garzia A, Waldron JA, Chatterjee S, McGirr T, Ladak RJ, Choi J, Luo J, Leino S, Jess N, Shariati SA, Soto Rodriguez X, Gkogkas CG, Sonenberg N, Tuschl T, Maguire S, Jafarnejad SM.   +17 more
europepmc   +1 more source

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Translation of Poliovirus mRNA

Enzyme, 2017
Ribosome binding to cellular eukaryotic mRNAs is proposed to occur by initial attachment at or near the mRNA 5' cap structure (m^7 GpppN, where N is any nucleotide) followed by scanning till the appropriate initiator AUG is encountered. A pivotal aspect of this model is the obligatory entry of the ribosomes at the 5' end of the mRNA (regardless if it ...
N, Sonenberg, K, Meerovitch
openaire   +2 more sources