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Translation and mRNA decay

Molecular and General Genetics MGG, 1978
Degradation of messenger RNA from the lactose operon (lac mRNA) was measured during the inhibition of protein synthesis by chloramphenicol (CM) or of translation-initiation by kasugamycin (KAS). With increasing CM concentration mRNA decay becomes slower, but there is no direct proportionality between rates of chemical decay and polypeptide synthesis ...
E, Schneider, M, Blundell, D, Kennell
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Nutrient Control of mRNA Translation

Annual Review of Nutrition, 2020
The emergence of genome-wide analyses to interrogate cellular DNA, RNA, and protein content has revolutionized the study of control networks that mediate cellular homeostasis. mRNA translation represents the last step of genetic flow and primarily defines the proteome.
Xin Erica, Shu   +2 more
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Selective translation of mRNAs at synapses

Current Opinion in Neurobiology, 2002
Synaptic efficacy, a phenomenon that may underlie long-term memory storage, is controlled in part by the regulated translation of mRNAs stored in dendrites. The molecular basis by which specific mRNAs are selected for translation is beginning to emerge and appears to involve at least one mechanism that helps program early metazoan development.
Joel D, Richter, Lori J, Lorenz
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Regulation of mRNA translation

Essays in Biochemistry, 2001
The control of mRNA translation plays an important role in regulating gene expression in diverse situations. Nutrients, especially amino acids, regulate translation to control the expression of specific proteins including transcriptional activators and ribosomal proteins.
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Control and regulation of mRNA translation

Biochemical Society Transactions, 2014
Translational control is central to the gene expression pathway and was the focus of the 2013 annual Translation UK meeting held at the University of Kent. The meeting brought together scientists at all career stages to present and discuss research in the mRNA translation field, with an emphasis on the presentations on the research of early career ...
Emma J, Mead   +4 more
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Translation of Rabbit Globin mRNA

Nature New Biology, 1972
IN certain conditions bacterial initiation factors can discriminate between different classes of mRNA, or the individual cistrons of bacteriophage RNA1–5. Whether messenger specificity is a general phenomenon in eukaryotes as well is controversial, but several reports support the idea that mRNAs can be translated in heterologous systems without the ...
SAMPSON J, BORGHETTI, Angelo
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Dendritic mRNA Targeting and Translation

2012
Selective targeting of specific mRNAs into neuronal dendrites and their locally regulated translation at particular cell contact sites contribute to input-specific synaptic plasticity. Thus, individual synapses become decision-making units, which control gene expression in a spatially restricted and nucleus-independent manner.
Stefan, Kindler   +1 more
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Identification of Actively Translated mRNAs

2014
Ribosomes are large protein-RNA complexes involved in translation of mRNA nucleotide sequences into proteins. Multiple ribosomes, polyribosomes (polysomes), bind to a single mRNA in order to initiate translation and protein synthesis. In order to distinguish actively translated RNAs, total polysomes can be isolated from cell lysates and purified by ...
Marc R, Reboll, Mahtab, Nourbakhsh
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Plastid mRNA Translation

2014
Overall translational machinery in plastids is similar to that of E. coli. Initiation is the crucial step for translation and this step in plastids is somewhat different from that of E. coli. Unlike the Shine-Dalgarno sequence in E. coli, cis-elements for translation initiation are not well conserved in plastid mRNAs.
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Reovirus mRNA: transcription and translation

Cell, 1976
Aaron J. Shatkin and Gerald W. Both Roche Institute of Molecular Biology Nutley, New Jersey 07110 Human reovirus type 3 is the prototype of a widely distributed group of animal, plant, and insect viruses that contain double-stranded RNA genomes (Joklik, 1974).
A J, Shatkin, G W, Both
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