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mRNA-Based Vaccines [PDF]

Vaccines, 2021
Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread.
Frank Kowalzik, Daniel Schreiner, Christian Jensen, Daniel Teschner, Stephan Gehring, Fred Zepp   +5 more
doaj   +3 more sources

Neo-Antigen mRNA Vaccines [PDF]

Vaccines, 2020
The interest in therapeutic cancer vaccines has caught enormous attention in recent years due to several breakthroughs in cancer research, among which the finding that successful checkpoint blockade treatments reinvigorate neo-antigen-specific T cells ...
Arthur Esprit, Wout de Mey, Rajendra Bahadur Shahi, Kris Thielemans, Lorenzo Franceschini, Karine Breckpot   +5 more
doaj   +4 more sources

mRNA Vaccines against Flaviviruses [PDF]

Vaccines, 2021
Numerous vaccines have now been developed using the mRNA platform. In this approach, mRNA coding for a viral antigen is in vitro synthesized and injected into the host leading to exogenous protein expression and robust immune responses.
Clayton J. Wollner, Justin M. Richner
doaj   +3 more sources

mRNA as a Therapeutics: Understanding mRNA Vaccines [PDF]

Advanced Pharmaceutical Bulletin, 2022
Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing ...
Ferdi Oğuz, Harika Atmaca
doaj   +3 more sources

Dangers of mRNA vaccines

Industrial Psychiatry Journal, 2021
“Necessity is the mother of invention:” An adage was brought to life with the emergence of the mRNA vaccine against the backdrop of the foreboding and mercurial COVID-19 pandemic.
Tahoora Ali, Swaleha Mujawar, A V Sowmya, Daniel Saldanha, Suprakash Chaudhury   +4 more
doaj   +3 more sources

Research progress of mRNA vaccines for infectious diseases. [PDF]

Eur J Med Res
mRNA vaccines for infectious diseases prevent diseases by stimulating the body to produce specific immune responses through mRNA molecules encoding pathogenic proteins.
Zhang Z, Du J, Zhang D, Han R, Wu X, Liang Y.   +5 more
europepmc   +2 more sources

mRNA Vaccines: Current Applications and Future Directions. [PDF]

MedComm (2020)
Messenger RNA (mRNA) vaccines, as a novel class of biotherapeutics, leverage mRNA technology to instruct cells to produce specific antigens, thereby inducing an immune response.
Li J, Liu Y, Dai J, Yang L, Xiong F, Xia J, Jin J, Wu Y, Peng X.   +8 more
europepmc   +2 more sources

mRNA vaccines for cancer immunotherapy

Frontiers in Immunology, 2022
Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA vaccines are an attractive and powerful immunotherapeutic platform against cancer because of their high potency, specificity, versatility, rapid and large-scale development ...
Yashavantha L. Vishweshwaraiah, Nikolay V. Dokholyan, Nikolay V. Dokholyan, Nikolay V. Dokholyan, Nikolay V. Dokholyan   +4 more
doaj   +3 more sources

mRNA vaccine for cancer immunotherapy [PDF]

Molecular Cancer, 2021
mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune
Lei Miao, Yu Zhang, Leaf Huang
doaj   +3 more sources

Development of mRNA rabies vaccines

Human Vaccines & Immunotherapeutics
Rabies, primarily transmitted to humans by dogs (accounting for 99% of cases). Once rabies occurs, its mortality rate is approximately 100%. Post-exposure prophylaxis (PEP) is critical for preventing the onset of rabies after exposure to rabid animals ...
Zixin Fang, Pengcheng Yu, Wuyang Zhu
doaj   +3 more sources