Results 171 to 180 of about 11,376 (201)

Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)

Archives of Biochemistry and Biophysics, 2007
The regulation of divalent zinc has been observed in a wide range of organisms. Since this metal is an essential nutrient, but also toxic in excess, zinc homeostasis is crucial for normal cellular functioning. The metal-responsive-element-binding transcription factor-1 (MTF-1) is a key regulator of zinc in higher eukaryotes ranging from insects to ...
John H, Laity, Glen K, Andrews
exaly   +3 more sources

Comparative analysis of MTF-1 binding sites between human and mouse

Mammalian Genome, 2010
MTF-1 is a crucial transcription factor involved in the cellular response to heavy-metal load and other stresses by specifically binding to metal response elements (MREs). Thus far only a handful of direct target genes are known for this transcription factor, limiting our understanding of the biological network it governs.
Minghui, Wang, Fan, Yang, Xiangzhe, Zhang, Hongbo, Zhao, Qishan, Wang, Yuchun, Pan   +5 more
openaire   +2 more sources

Identification and characterization of two mtf-1 genes in common carp

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2008
The Metal-responsive Transcription Factor (MTF-1) serves as an essential regulator of Zn(2+) homeostasis via the activation of metallothionein gene expression. Only a single mtf-1 gene has been identified in any organism investigated previously. We report here the first evidence of the existence of two genes encoding MTF-1 proteins (mtf-1.1 and mtf-1.2)
Agnes, Ferencz, Edit, Hermesz
openaire   +2 more sources

Characterization of the MTF-1 transcription factor from zebrafish and trout cells

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000
The metal response element (MRE)-binding transcription factor-1, MTF-1, is a zinc-responsive protein that controls transcription of metallothionein (MT) genes in many cell types. In addition, MTF-1 is also hypothesized to regulate transcription of a battery of genes involved in the defense against oxidative stress.
T P, Dalton, W A, Solis, D W, Nebert, M J, Carvan   +3 more
openaire   +2 more sources

Zinc suppresses hepatic Zip10 expression through activation of MTF‐1

The FASEB Journal, 2007
The Zip transporter family acts to increase the intracellular zinc concentration. The mechanisms of regulation are largely unknown. Recently, hepatic Zip10 expression was shown to increase in vivo in the absence of metal‐responsive transcription factor‐1 (MTF‐1).
Louis A. Lichten, Juan P. Liuzzi, Robert J. Cousins   +2 more
openaire   +1 more source

Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.

The EMBO Journal, 1993
Metallothioneins (MTs) are small cysteine-rich proteins whose structure is conserved from fungi to man. MTs strongly bind heavy metals, notably zinc, copper and cadmium. Upon exposure of cells to heavy metal and other adverse treatments, MT gene transcription is strongly enhanced.
F, Radtke, R, Heuchel, O, Georgiev, M, Hergersberg, M, Gariglio, Z, Dembic, W, Schaffner   +6 more
openaire   +2 more sources

Cellular zinc sensors: MTF-1 regulation of gene expression

Biometals, 2001
Zinc metabolism in higher eukaryotes is complex, being controlled by uptake, efflux, and storage in individual cells, as well as in peripheral tissues and organs. Recently there have been advances in the understanding of the genes involved in these processes and their regulation.
openaire   +2 more sources

Induction of Fetal Hemoglobin by Transcriptional Co-Activators MTF-1 and TSPYL1

Blood, 2011
Abstract Abstract 353 Sickle cell disease (SCD) impacts one of 400 African-Americans born each year. Augmentation of fetal hemoglobin (HbF) levels is widely accepted as the most effective method for treating SCD, but hydroxyurea (HU) is currently the only approved drug that increases HbF.
Kenneth R Peterson, Flavia C Costa, Halyna Fedosyuk, Renee Neades, Johana Bravo de los Rios, Andrea Fonteles, Lesya Zelenchuk, Prarthana Dalal, Gabriella Maniscalco   +8 more
openaire   +1 more source

Metal Response Element (MRE)-Binding Transcription Factor-1 (MTF-1): Structure, Function, and Regulation

Antioxidants & Redox Signaling, 2001
Metal-responsive control of the expression of genes involved in metal metabolism and metal homeostasis allows an organism to tightly regulate the free or bioavailable concentration of beneficial metal ions, such as zinc, copper, and iron, within an acceptable range, while efficiently removing nonbeneficial or toxic metals.
D P, Giedroc, X, Chen, J L, Apuy
openaire   +2 more sources