Results 181 to 190 of about 11,376 (201)

Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse

Somatic Cell and Molecular Genetics, 1995
Heavy metal-induced transcription in mammalian cells is conferred by the metal-responsive 70 kDa transcription factor MTF-1 which contains six zinc fingers and at least three activation domains. In previous cell transfection experiments we have shown that the zinc finger region confers an about 3 fold metal inducibility of transcription, due to its ...
H P, Müller, E, Brungnera, O, Georgiev, M, Badzong, K H, Müller, W, Schaffner   +5 more
openaire   +2 more sources

Putting its fingers on stressful situations: the heavy metal‐regulatory transcription factor MTF‐1

BioEssays, 2001
AbstractIt has been suggested that metallothioneins, discovered about 45 years ago, play a central role in heavy metal metabolism and detoxification, and in the management of various forms of stress. The metal‐regulatory transcription factor‐1 (MTF‐1) was shown to be essential for basal and heavy metal‐induced transcription of the stress‐responsive ...
P, Lichtlen, W, Schaffner
openaire   +2 more sources

Zinc-sensitive genes as potential new target genes of the metal transcription factor-1 (MTF-1)

Biochemistry and Cell Biology, 2005
Zinc is an essential trace element that serves as a structural constituent of a large number of transcription factors, which explains its pivotal role in the control of gene expression. Previous studies investigating the effect of zinc deficiency and zinc supplementation on gene expression in the human adenocarcinoma cell line HT-29 led to the ...
Birgit, Kindermann, Frank, Döring, Jan, Budczies, Hannelore, Daniel   +3 more
openaire   +2 more sources

Identification of a splice variant of the metal-responsive transcription factor MTF-1 in common carp

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2009
Transactivation of the expression of metallothionein genes involves the Metal-responsive Transcription Factor (MTF-1). We report here the identification of mtf-1.1a, the first known splice variant of mtf-1.1 mRNA, in common carp (Cyprinus carpio).
Agnes, Ferencz, Edit, Hermesz
openaire   +2 more sources

Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1α and MTF-1

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2004
Solid tumors are known to develop microenvironmental hypoxia or anoxia due to malfunction and malformation of blood vessels and the energy demands of the highly proliferative tumor cells. Oxygen deprivation can cause aberrant modifications of signaling pathways and their downstream transcription factors that are believed to contribute to malignancy ...
openaire   +2 more sources

Cadmium induced cerebral toxicity via modulating MTF1-MTs regulatory axis

Environmental Pollution, 2021
Milton Talukder, Jin-Long Li
exaly  

MTF-1

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h

Cell Reports, 2021
Tongmei Zhang, Xian Huang, Qingping Zhang   +2 more
exaly  

Reduced N6‐Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth

Chemistry and Biodiversity, 2022
Ying Yang, Xing Zhong Wu
exaly  

WDR26 and MTF2 are therapeutic targets in multiple myeloma

Journal of Hematology and Oncology, 2021
Fumou Sun, Yan Cheng, Jesse D Riordan
exaly