Results 11 to 20 of about 11,376 (201)

Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione [PDF]

open access: yesNucleic Acids Research, 2005
Metal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1
Walter Schaffner
exaly   +4 more sources

The "metal transcription factor" MTF-1: biological facts and medical implications

open access: yesSwiss Medical Weekly, 2001
Metallothioneins (MTs) are a class of small, cysteine-rich proteins that have an important function in heavy metal metabolism and detoxification and in the management of various forms of cell stress. Several lines of evidence suggest a role for metallothioneins in therapy resistance of malignant tumours, regulation of blood pressure and protection ...
P Lichtlen, W Schaffner
doaj   +3 more sources

Ameliorative effects of combination therapy with metformin and crocin in experimental colitis in rats [PDF]

open access: yesResearch in Pharmaceutical Sciences
Background and purpose: Inflammatory bowel disease (IBD) is characterized by aberrant immune responses in the colon, leading to the inflammatory cascades.
Bahare Koohshekan   +3 more
doaj   +2 more sources

Retrospective analysis of restoration of the anatomy of the damaged thoracic and lumbar spinal motion segment using transpedicular repositioning device

open access: yesХирургия позвоночника, 2022
Objective. To carry out a retrospective analysis of the restoration of the anterior and posterior vertebral body heights and the elimination of deformation of the anterior spinal canal wall caused by thoracic and lumbar spine injury, based on the data of
Vladimir D. Usikov   +2 more
doaj   +1 more source

Metal-Regulatory Transcription Factor-1 Targeted by miR-148a-3p Is Implicated in Human Hepatocellular Carcinoma Progression

open access: yesFrontiers in Oncology, 2021
Metal-regulatory transcription factor-1 (MTF-1) is of importance in maintaining metal homeostasis. Copper exposure considerably stimulates the proliferation of hepatocellular carcinoma (HCC) cells with enhanced MTF-1 expression.
Zhuozhen Lyu   +4 more
doaj   +1 more source

Divalent metal‐dependent regulation of hepcidin expression by MTF‐1 [PDF]

open access: yesFEBS Letters, 2009
Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE‐binding transcription factor‐1 ...
Balesaria, Sara   +4 more
openaire   +2 more sources

AN IMPROVED HIGH FREQUENCY MODULATING FUSION METHOD BASED ON MODULATION TRANSFER FUNCTION FILTERS [PDF]

open access: yesISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2012
GeoEye-1 is the most advanced and highest resolution commercial earth imaging satellite in the world today. It provides multispectral images (MS) and Panchromatic image (PAN) with spatial resolutions of 2.0 m and 0.5 m respectively.
Y. Jia, M. Wu, X. Zhang
doaj   +1 more source

Measurement of damaged segment deformity in the thoracic and lumbar spine with spiral computed tomography to calculate the required correction

open access: yesГений oртопедии, 2022
Introduction The more accurate is the measurement of the parameters for correcting the deformity of damaged spinal segments the more accurate will be the restoration of the sagittal profile and original anatomy of the spine.
Vladimir D. Usikov   +2 more
doaj   +1 more source

Research on the Coupled Modulation Transfer Function of the Discrete Sampling System with Hexagonal Fiber-Optic Imaging Bundles

open access: yesApplied Sciences, 2022
In this study, we developed a numerical model of the coupled modulation transfer function (coupled-MTF) based on the discrete sampling system from the perspective of optical system imaging quality evaluation for coupled two-dimensional discrete sampling ...
Wenxian Li   +4 more
doaj   +1 more source

New Metformin–Citric Acid Pharmaceutical Molecular Salt: Improving Metformin Physicochemical Properties

open access: yesCrystals, 2022
Crystal engineering and, more specifically, the development of multicomponent materials has become an effective technique to rationally modify important physicochemical properties of solids, such as solubility and thermal stability.
Cristóbal Verdugo-Escamilla   +4 more
doaj   +1 more source

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