Results 21 to 30 of about 21,251,406 (232)

A T > G Mutation in the NR5A2 Gene Is Associated With Litter Size in Hu Sheep Through Upregulation of Promoter Activity by Transcription Factor MTF-1 [PDF]

Frontiers in Genetics, 2019
Nuclear receptor subfamily 5 group A member 2 (NR5A2), also referred to as LRH-1 or FTF, is an orphan nuclear hormone receptor that is involved in regulating embryonic development, ovarian granulosa cell differentiation, gonadal sex differentiation, and ...
Yinxia Li, Yinxia Li, Jun Zhang, Jun Zhang, Yong Qian, Yong Qian, Chunhua Meng, Chunhua Meng, Huili Wang, Huili Wang, Jifeng Zhong, Jifeng Zhong, Shaoxian Cao, Shaoxian Cao   +13 more
doaj   +2 more sources

Target gene search for the metal-responsive transcription factor MTF-1 [PDF]

Nucleic Acids Research, 2001
Activation of genes by heavy metals, notably zinc, cadmium and copper, depends on MTF-1, a unique zinc finger transcription factor conserved from insects to human. Knockout of MTF-1 in the mouse results in embryonic lethality due to liver decay, while knockout of its best characterized target genes, the stress-inducible metallothionein genes I and II ...
Lichtlen P, Wang Y, Belser T, Georgiev O, Certa U, Sack R, Schaffner W   +6 more
openaire   +5 more sources

The Heavy Metal-Responsive Transcription Factor-1 (MTF-1) Is Not Required for Neural Differentiation [PDF]

Biological Chemistry, 1999
AbstractThe zinc finger transcription factor MTF-1 is essential for proper response to heavy metal load and other stress conditions in vertebrates, and also contributes to the maintenance of the cellular redox state. Target genes include metallothioneins (MT-I and MT-II) and gamma-glutamylcysteine synthetase (gamma-GCS), an enzyme involved in ...
Lichtlen, P, Georgiev, O, Schaffner, W, Aguzzi, A, Brandner, S   +4 more
openaire   +6 more sources

Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux

Blood, 2010
Ferroportin (Fpn) is the only known iron exporter in vertebrate cells and plays a critical role in iron homeostasis regulating cytosolic iron levels and exporting iron to plasma. Ferroportin1 (FPN1) expression can be transcriptionally regulated by iron as well as other transition metals.
Troadec, Marie-Berengere, Ward, Diane Mcvey, Lo, Eric, Kaplan, Jerry, de Domenico, Ivana   +4 more
openaire   +5 more sources

Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione [PDF]

Nucleic Acids Research, 2005
Metal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1
Wimmer U, Wang Y, Georgiev O, Schaffner W   +3 more
core   +6 more sources

Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1

Nucleic Acids Research, 1994
Metallothioneins (MTs) are small cysteine-rich proteins that bind heavy metal ions such as zinc, cadmium and copper with high affinity, and have been functionally implicated in heavy metal detoxification and radical scavenging. Transcription of metallothioneins genes is induced by exposure of cells to heavy metals.
Brugnera E, Georgiev O, Radtke F, Heuchel R, Baker E, Sutherland GR, Schaffner W   +6 more
core   +6 more sources

The "metal transcription factor" MTF-1: biological facts and medical implications

Swiss Medical Weekly, 2001
Metallothioneins (MTs) are a class of small, cysteine-rich proteins that have an important function in heavy metal metabolism and detoxification and in the management of various forms of cell stress. Several lines of evidence suggest a role for metallothioneins in therapy resistance of malignant tumours, regulation of blood pressure and protection ...
P Lichtlen, W Schaffner
doaj   +3 more sources

The Zinc-Sensing Mechanism of Mouse MTF-1 Involves Linker Peptides between the Zinc Fingers [PDF]

Molecular and Cellular Biology, 2006
Mouse metal response element-binding transcription factor-1 (MTF-1) regulates the transcription of genes in response to a variety of stimuli, including exposure to zinc or cadmium, hypoxia, and oxidative stress. Each of these stresses may increase labile cellular zinc, leading to nuclear translocation, DNA binding, and transcriptional activation of ...
Yong, Li, Tomoki, Kimura, John H, Laity, Glen K, Andrews   +3 more
openaire   +3 more sources

Retrospective analysis of restoration of the anatomy of the damaged thoracic and lumbar spinal motion segment using transpedicular repositioning device

Хирургия позвоночника, 2022
Objective. To carry out a retrospective analysis of the restoration of the anterior and posterior vertebral body heights and the elimination of deformation of the anterior spinal canal wall caused by thoracic and lumbar spine injury, based on the data of
Vladimir D. Usikov, Vladimir S. Kuftov, Dmitry N. Monashenko   +2 more
doaj   +1 more source

Metal-Regulatory Transcription Factor-1 Targeted by miR-148a-3p Is Implicated in Human Hepatocellular Carcinoma Progression

Frontiers in Oncology, 2021
Metal-regulatory transcription factor-1 (MTF-1) is of importance in maintaining metal homeostasis. Copper exposure considerably stimulates the proliferation of hepatocellular carcinoma (HCC) cells with enhanced MTF-1 expression.
Zhuozhen Lyu, Mingyu Yang, Tan Yang, Mingze Ma, Zhen Yang   +4 more
doaj   +1 more source