Results 21 to 30 of about 13,421 (232)
Crystals, 2022 Crystal engineering and, more specifically, the development of multicomponent materials has become an effective technique to rationally modify important physicochemical properties of solids, such as solubility and thermal stability.
Cristóbal Verdugo-Escamilla +4 more
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The Transcription Factor MTF-1 Mediates Metal Regulation of the Mouse ZnT1 Gene [PDF]
Journal of Biological Chemistry, 2000 Metal regulation of the mouse zinc transporter (ZnT)-1 gene was examined in cultured cells and in the developing conceptus. Zinc or cadmium treatment of cell lines rapidly (3 h) and dramatically (about 12-fold) induced ZnT1 mRNA levels. In cells incubated in medium supplemented with Chelex-treated fetal bovine serum, to remove metal ions, levels of ...
S J, Langmade +3 more
openaire +2 more sources
Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine
Vaccines, 2020 We previously reported that topical imiquimod can improve the immunogenicity of the influenza vaccine. This study investigated another FDA-approved drug, miltefosine (MTF), as a vaccine adjuvant.
Lu Lu +13 more
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Fisheries and Aquatic Sciences, 2017 Background Metal-responsive transcription factor-1 (MTF-1) is a key transcriptional regulator playing crucial roles in metal homeostasis and cellular adaptation to diverse oxidative stresses. In order to understand cellular pathways associated with metal
Sang Yoon Lee, Yoon Kwon Nam
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Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP [PDF]
Nucleic Acids Research, 2012 Dnmt1 is frequently overexpressed in cancers, which contributes significantly to cancer-associated epigenetic silencing of tumor suppressor genes. However, the mechanism of Dnmt1 overexpression remains elusive. Herein, we elucidate a pathway through which nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive ...
Zhang, Yuxia, Andrews, Glen K., Wang, Li
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Omni-Akuatika, 2017 Heavy metal cadmium has toxic effects in the bodies of living organisms.However, the bodies of living organisms have the ability to regulate a wide range of toxic entering the body by using biomolecular response that aims at maintaining cell homeostasis.
Dominggus Rumahlatu
doaj +1 more source
Acta Medica Iranica, 2022 To compare Modulation Transform Function (MTF) between standard monofocal spherical hydrophobic acrylic Alcon SA60AT (Bausch and Lomb) and hydrophilic acrylic Rayner Superflex (620H) (Rayner) intra-ocular lenses (IOLs).
Tahereh Abdolahinia +7 more
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Functional domains of the heavy metal-responsive transcription regulator MTF-1
Nucleic Acids Research, 1995 Metallothioneins (MTs) constitute a class of low molecular weight, cysteine-rich, metal binding proteins which are regulated at the level of gene transcription in response to heavy metals and other adverse treatments. We have previously cloned a zinc finger factor (MTF-1) that binds specifically to heavy metal-responsive DNA sequence elements in ...
F, Radtke +4 more
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Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases [PDF]
Brazilian Journal of Pharmaceutical SciencesMetformin hydrochloride (MTF) has pharmacological properties for managing inflammatory skin conditions. MTF is a hydrophilic medication. Accordingly, embedding MTF into lipid carriers for enhancing skin penetration presents a challenge. The study aims to
Reem Y. Mahran +3 more
doaj +1 more source
Single nucleotide in the MTF-1 binding site can determine metal-specific transcription activation [PDF]
Proceedings of the National Academy of Sciences, 2012 Cells respond to changes in environment by shifting their gene expression profile to deal with the new conditions. The cellular response to changes in metal homeostasis is an important example of this. Transition metals such as iron, zinc, and copper are essential micronutrients but other metals such as cadmium are simply toxic.
Hillel I, Sims +2 more
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