Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells [PDF]
Cells, 2023 (1) Background: Metal homeostasis is an important part of cellular programs and is disrupted when cells are exposed to carcinogenic heavy metals. Metal response is mediated by the metal response element transcription factor MTF-1.
Joshua C Black
exaly +7 more sources
Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development [PDF]
Biochimica Et Biophysica Acta - Molecular Cell Research, 2014 The metal responsive element-binding transcription factor-1 (MTF-1) responds to changes in cellular zinc levels caused by zinc exposure or disruption of endogenous zinc homeostasis by heavy metals or oxygen-related stress. Here we report the functional characterization of a complete zebrafish MTF-1 in comparison with the previously identified isoform ...
Andrew G Mcarthur +2 more
exaly +5 more sources
The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke [PDF]
Cell Death and Disease, 2021 Remote limb ischemic postconditioning (RLIP) is an experimental strategy in which short femoral artery ischemia reduces brain damage induced by a previous harmful ischemic insult.
Valeria Valsecchi +6 more
doaj +3 more sources
The taste of heavy metals: Gene regulation by MTF-1
Biochimica Et Biophysica Acta - Molecular Cell Research, 2012 The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator involved in cellular adaptation to various stress conditions, primarily exposure to heavy metals but also to hypoxia or oxidative stress.
Viola GÜNTHER, Walter Schaffner
exaly +5 more sources
Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1 [PDF]
EMBO Journal, 1998 We have shown previously that the heavy metal-responsive transcriptional activator MTF-1 regulates the basal and heavy metal-induced expression of metallothioneins. To investigate the physiological function of MTF-1, we generated null mutant mice by targeted gene disruption. Embryos lacking MTF-1 die in utero at approximately day 14 of gestation.
Rainer Heuchel +2 more
exaly +7 more sources
Ferroptosis-related gene MTF-1 as a novel prognostic biomarker in low-grade glioma and its correlation with immune infiltration [PDF]
Heliyon, 2023 Background: Metal-responsive transcription factor-1 performs a necessary position in a range of cancers. It is unknown, though, how the prognosis of patients with low-grade gliomas is related to immune infiltration.
Huaixu Li +5 more
doaj +2 more sources
Automatic MTF Conversion between Different Characteristics Caused by Imaging Devices
Journal of ImagingDepending on various design conditions, including optics and circuit design, the image-forming characteristics of the modulated transfer function (MTF), which affect the spatial resolution of a digital image, may vary among image channels within or ...
Midori Tanaka, Takahiko Horiuchi
exaly +4 more sources
Gawky modulates MTF-1-mediated transcription activation and metal discrimination. [PDF]
Nucleic Acids Res, 2021 Abstract Metal-induced genes are usually transcribed at relatively low levels under normal conditions and are rapidly activated by heavy metal stress. Many of these genes respond preferentially to specific metal-stressed conditions. However, the mechanism by which the general transcription machinery discriminates metal stress from normal
Jia R +5 more
europepmc +4 more sources
ANALISIS ALGORITMA MTF, MTF-1 DAN MTF-2 PADA BURROWS WHEELER COMPRESSION ALGORITHM
JUTEI (Jurnal Terapan Teknologi Informasi), 2019 Kebutuhan kompresi data teks di era komputasi awan saat ini masih cukup tinggi. Data teks perlu dikompresi sekecil mungkin agar mudah dikirimkan. Burrows Wheeler Compression Algorithm (BWCA) adalah salah satu algoritma kompresi teks jenis block sorting ...
Sagara Mahardika Sunaryo +2 more
doaj +2 more sources
PLoS ONE, 2011 The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh +2 more
doaj +2 more sources