Results 21 to 30 of about 11,376 (201)
Molecular Mechanisms of MTF‐1 Metalloregulation
The FASEB Journal, 2006 In humans and other higher eukaryotes, the metal‐responsive element‐binding transcription factor‐1 (MTF‐1) coordinates the expression of genes involved in Zn(II) homeostasis, metal ion detoxification and protection against oxidative stress.
John H Laity +5 more
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Foods, 2022 This work provides a novel approach to monitor the aflatoxin B1 (AFB1) content in maize by near-infrared (NIR) spectra-based deep learning models that integrates Markov transition field (MTF) image coding and a convolutional neural network (CNN) strategy.
Bo Wang, Jihong Deng, Hui Jiang
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Transcription Factor MTF-1 Involved in the Cellular Response to Zinc
YAKUGAKU ZASSHI, 2021 Heavy metals, both toxic and essential, have long been an important research focus in life science. To investigate the intracellular actions of heavy metals at the molecular level, I have been exploring protein factors involved in induction of metallothionein (MT) genes by heavy metals that specifically bind to a metal responsive element (MRE) in the ...
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The Transcription Factor MTF-1 Mediates Metal Regulation of the Mouse ZnT1 Gene [PDF]
Journal of Biological Chemistry, 2000 Metal regulation of the mouse zinc transporter (ZnT)-1 gene was examined in cultured cells and in the developing conceptus. Zinc or cadmium treatment of cell lines rapidly (3 h) and dramatically (about 12-fold) induced ZnT1 mRNA levels. In cells incubated in medium supplemented with Chelex-treated fetal bovine serum, to remove metal ions, levels of ...
S J, Langmade +3 more
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Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine
Vaccines, 2020 We previously reported that topical imiquimod can improve the immunogenicity of the influenza vaccine. This study investigated another FDA-approved drug, miltefosine (MTF), as a vaccine adjuvant.
Lu Lu +13 more
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Fisheries and Aquatic Sciences, 2017 Background Metal-responsive transcription factor-1 (MTF-1) is a key transcriptional regulator playing crucial roles in metal homeostasis and cellular adaptation to diverse oxidative stresses. In order to understand cellular pathways associated with metal
Sang Yoon Lee, Yoon Kwon Nam
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Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP [PDF]
Nucleic Acids Research, 2012 Dnmt1 is frequently overexpressed in cancers, which contributes significantly to cancer-associated epigenetic silencing of tumor suppressor genes. However, the mechanism of Dnmt1 overexpression remains elusive. Herein, we elucidate a pathway through which nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive ...
Zhang, Yuxia, Andrews, Glen K., Wang, Li
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Acta Medica Iranica, 2022 To compare Modulation Transform Function (MTF) between standard monofocal spherical hydrophobic acrylic Alcon SA60AT (Bausch and Lomb) and hydrophilic acrylic Rayner Superflex (620H) (Rayner) intra-ocular lenses (IOLs).
Tahereh Abdolahinia +7 more
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Omni-Akuatika, 2017 Heavy metal cadmium has toxic effects in the bodies of living organisms.However, the bodies of living organisms have the ability to regulate a wide range of toxic entering the body by using biomolecular response that aims at maintaining cell homeostasis.
Dominggus Rumahlatu
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Functional domains of the heavy metal-responsive transcription regulator MTF-1
Nucleic Acids Research, 1995 Metallothioneins (MTs) constitute a class of low molecular weight, cysteine-rich, metal binding proteins which are regulated at the level of gene transcription in response to heavy metals and other adverse treatments. We have previously cloned a zinc finger factor (MTF-1) that binds specifically to heavy metal-responsive DNA sequence elements in ...
F, Radtke +4 more
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