Results 81 to 90 of about 13,421 (232)

Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.

PLoS ONE, 2011
The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh, Josephine A Wright, David R Brown   +2 more
doaj   +1 more source

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability [PDF]

, 2017
Amyloid plaques consisting of aggregated Aβ peptide are a hallmark of Alzheimer's disease. Among the different forms of Aβ, the one of 42aa length (Aβ42) is most aggregation-prone and also the most neurotoxic.
Georgiev, Oleg, Harmeier, Anja, Hua, Haiqing, Multhaup, Gerd, Münter, Lisa, Schaffner, Walter   +5 more
core  

Hawaiian Picture‐Winged Drosophila Exhibit Adaptive Population Divergence along a Narrow Climatic Gradient on Hawaii Island [PDF]

, 2019
1. Anthropogenic influences on global processes and climatic conditions are increasingly affecting ecosystems throughout the world. 2. Hawaii Island’s native ecosystems are well studied and local long‐term climatic trends well documented, making these ...
Bellinger, M. Renee, Eldon, Jon, Price, Donald K.   +2 more
core   +2 more sources

MTF-1-Mediated Repression of the Zinc Transporter Zip10 Is Alleviated by Zinc Restriction

PLoS ONE, 2011
The regulation of cellular zinc uptake is a key process in the overall mechanism governing mammalian zinc homeostasis and how zinc participates in cellular functions. We analyzed the zinc transporters of the Zip family in both the brain and liver of zinc-deficient animals and found a large, significant increase in Zip10 expression.
Louis A Lichten, Moon-Suhn Ryu, Liang Guo, Jennifer Embury, Robert J Cousins   +4 more
openaire   +4 more sources

Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level [PDF]

Acta Biochimica Polonica, 2015
Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response.
Agata, Grzywacz, Joanna, Gdula-Argasińska, Bożena, Muszyńska, Małgorzata, Tyszka-Czochara, Tadeusz, Librowski, Włodzimierz, Opoka   +5 more
openaire   +2 more sources

Advances and Current Progress of Dopant Engineering on All‐Inorganic Halide Perovskites Toward High‐Performance Scintillating Materials

MetalMat, EarlyView.
This review provides the latest advancement on lead‐free all‐inorganic perovskites, covering fundamental aspects, emerging synthetic routes, and scintillation properties. We highlight the dopant engineering strategy to favor the formation and efficient radiative recombination of self‐trapped excitons and the future development direction for the next ...
Galfin Anderias Adu, Viona Maria Djojo, Livia Janice Widiapradja, Noor Nisa Fayyaza, Lina Jaya Diguna, Muhammad Danang Birowosuto, Arramel Arramel   +6 more
wiley   +1 more source

Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway

Stem Cell Research & Therapy
Background Despite the existence of promising outcomes from standard 2D culture systems, these data are not completely akin to in vivo tumor parenchyma. Therefore, the development and fabrication of various 3D culture systems can in part mimic intricate ...
Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi   +10 more
doaj   +1 more source

Biological and molecular characterisation of in vitro selected miltefosine-resistant Leishmania amazonensis lines

International Journal for Parasitology: Drugs and Drug Resistance
Miltefosine (MTF) is currently the only available oral treatment for leishmaniasis. However, increasing reports of therapeutic failure have raised concerns about emerging resistance.
Laura Fernanda Neira, Héllida Marina Costa-Silva, Juliana Martins Ribeiro, Silvane Maria Fonseca Murta, Patricia Escobar   +4 more
doaj   +1 more source

Bond Graph Multi-time Scale Analysis of a Railway Traction System [PDF]

, 2001
The unified formalism of bond graphs is applicable to designing, modeling and analyzing complex and heterogeneous physical systems. Moreover, various order-reduction methods can be applied directly on bond graph models in order to simplify them.
Dauphin-Tanguy, Geneviève, Gandanegara, Grace, Roboam, Xavier, Sareni, Bruno   +3 more
core  

The moment $\langle x\rangle_{u-d}$ of the nucleon from $N_f=2$ lattice QCD down to nearly physical quark masses

, 2014
We present an update of our analysis [1] which includes additional ensembles at different quark masses, lattice spacings and volumes, all with high statistics.
Bali, Gunnar S., Collins, Sara, Gläßle, Benjamin, Göckeler, Meinulf, Najjar, Johannes, Rödl, Rudolf H., Schiel, Rainer W., Schäfer, Andreas, Sternbeck, André, Söldner, Wolfgang   +9 more
core   +1 more source