Results 71 to 80 of about 13,421 (232)

Metformin Reduces Viability and Inhibits the Immunoinflammatory Profile of Human Glioblastoma Multiforme Cells

Neuroglia
Glioblastoma (GBM) is the predominant primary malignant brain tumor. Metformin, a well-known antidiabetic medication, has emerged as a potential therapeutic candidate in the treatment of GBM.
Daewoo Hong, Regina Ambe, Jose Barragan, Kristina Marie Reyes, Jorge Cervantes   +4 more
doaj   +1 more source

One-year effect of wearing orthokeratology lenses on the visual quality of juvenile myopia: a retrospective study [PDF]

PeerJ, 2019
Objective To study the one-year effect of wearing orthokeratology (OK) lenses on the visual quality of juvenile myopia. Methods The right eyes of 36 juvenile myopias were retrospectively studied in this work.
Yewei Yin, Yang Zhao, Xiaoying Wu, Mengyang Jiang, Xiaobo Xia, Yao Chen, Weitao Song, Shengfa Hu, Xia Zhou, Kelly Young, Dan Wen   +10 more
doaj   +2 more sources

Flexible Direct‐Conversion X‐Ray Detectors: From Emerging Materials to Conformal Imaging

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This comprehensive review analyzed the performance, challenges, and future directions of four emerging material systems for next‐generation flexible direct‐conversion X‐ray detectors: organic semiconductors, perovskites, metal–organic frameworks, and inorganic metal compounds.
Haipeng Di, Guoliang Ma, Jiaxin Mu, Kailian Dong, Haibin Li, Manjing Wang, Xin Song, Haojin Li, Jianwei Xu, Yiying Zhao, Jingjing Zhao, Guojia Fang   +11 more
wiley   +1 more source

Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster [PDF]

, 2017
Drosophila melanogaster MTF-1 (dMTF-1) is a copper-responsive transcriptional activator that mediates resistance to Cu, as well as Zn and Cd. Here, we characterize a novel cysteine-rich domain which is crucial for sensing excess intracellular copper by ...
Balamurugan, Kuppusamy, Chen, Xiaohua, George, Graham N., Georgiev, Oleg, Giedroc, David P., Hua, Haiqing, Kong, Xiangming, Schaffner, Walter, Zhang, Limei   +8 more
core  

Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1

Nucleic Acids Research, 1994
Metallothioneins (MTs) are small cysteine-rich proteins that bind heavy metal ions such as zinc, cadmium and copper with high affinity, and have been functionally implicated in heavy metal detoxification and radical scavenging. Transcription of metallothioneins genes is induced by exposure of cells to heavy metals.
E, Brugnera, O, Georgiev, F, Radtke, R, Heuchel, E, Baker, G R, Sutherland, W, Schaffner   +6 more
openaire   +3 more sources

The mediating role of shame in the relationship between adolescent hairpulling and co‐occurring anxiety and depressive symptomology

JCPP Advances, EarlyView.
This study found that shame is a significant mediator in positive associations between hairpulling severity and depression and anxiety severity within a community sample of adolescents with clinical levels of hair‐pulling severity. It also found high levels of trance‐pulling and post‐pulling rituals.
Talia F. Mayerson, Clare Mackay, Polly Waite   +2 more
wiley   +1 more source

Interface healing and its correlation with visual recovery and quality of vision following small incision lenticule extraction

Indian Journal of Ophthalmology, 2018
Purpose: To study the time course of interface healing and its correlation with visual acuity, modulation transfer function (MTF), and aberrations after myopic small-incision lenticule extraction (SMILE) correction.
Sri Ganesh, Sheetal Brar, Rahul Pandey, Archana Pawar   +3 more
doaj   +1 more source

Characterization of the mouse gene for the heavy metal-responsive transcription factor MTF-1

Cell Stress & Chaperones, 2000
MTF-1 is a zinc finger transcription factor that mediates the cellular response to heavy metal stress; its targeted disruption in the mouse leads to liver decay and embryonic lethality at day E14. Recently, we have sequenced the entire MTF-1 gene in the compact genome of the pufferfish Fugu rubripes. Here we have defined the promoter sequences of human
A, Auf der Maur, T, Belser, Y, Wang, C, Günes, P, Lichtlen, O, Georgiev, W, Schaffner   +6 more
openaire   +3 more sources

Listening in: Orthopaedic Oncology Physicians' Perspectives on Implementation of Audio Recording/Artificial Intelligence Assist in Office Visits

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction With rapid expansion of artificial intelligence (AI) in clinical documentation, responsible implementation of this tool is imperative in preserving the patient‐physician relationship. Orthopaedic oncologists were surveyed to assess their utilization of, and attitudes towards, ambient listening software.
Megan Hsu, Annemarie K. Leonard, Sean McGarry, Tessa Balach   +3 more
wiley   +1 more source

Evaluation of copper nanocatalyst performance in S-methyl thioformate synthesis from carbon monoxide: Structural and mechanistic insights

Results in Chemistry
S-methyl thioformate (MTF) holds promise in pharmaceutical applications due to its antimicrobial properties and role in synthesizing therapeutic agents for diseases such as cancer and diabetes.
Fatemeh Fallah Eri Sofla, Leila Mahdavian, Azam Marjani   +2 more
doaj   +1 more source