Results 181 to 190 of about 75,068 (344)
Chronic Diseases and Translational Medicine, EarlyView.ABSTRACT Background The ratio of high‐density lipoprotein cholesterol (HDL‐C) to low‐density lipoprotein cholesterol (LDL‐C) predicts cardiovascular disease (CVD) endpoints, yet its prognostic validity in high‐risk populations and for type 2 diabetes mellitus (T2DM)‐related adverse events remains unestablished. Methods This study included 32,609 people
Biting Lin +10 more
wiley +1 more source
Tuning mTORC1 Activity for Balanced Self-Renewal and Differentiation [PDF]
, 2010 Larissa S. Carnevalli, Andreas Trumpp
openalex +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis
Stem Cell Reports, 2018 Summary: The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) regulates cellular function in various cell types. Although the role of mTORC1 in skeletogenesis has been investigated previously, here we show a critical role of mTORC1/4E-BPs ...
Takashi Iezaki +15 more
doaj
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Noncanonical TGF-β pathways, mTORC1 and Abl, in renal interstitial fibrogenesis
, 2009 Shinong Wang +3 more
openalex +2 more sources
Food Frontiers, EarlyView.Obesity is a global health problem that requires research and regulatory attention. This research aims to investigate transcriptome‐wide changes induced by Vigna umbellata (Tsuruazuki) using a stem cell‐based tool and preadipocytes to explore its untapped potential as a functional food for anti‐obesity applications.
Elda Nurafnie Ibnu Rasid +6 more
wiley +1 more source
p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway [PDF]
, 2011 Angeles Durán +8 more
openalex +1 more source
The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance
Glia, EarlyView.Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons during rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic lipids and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production of ...
Rose Follis +2 more
wiley +1 more source