Results 191 to 200 of about 75,068 (344)

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy [PDF]

, 2011
Megan V. Astle, Katherine M. Hannan, Puiyee Ng, Rachel Lee, Amee J. George, Andy Hsu, Ygal Haupt, Ross D. Hannan, Richard B. Pearson   +8 more
openalex   +1 more source

Sestrin2 is a leucine sensor for the mTORC1 pathway

Science, 2016
Rachel L. Wolfson, Lynne Chantranupong, R. A. Saxton, K. Shen, Sonia M. Scaria, J. Cantor, D. Sabatini   +6 more
semanticscholar   +1 more source

Environmental Sensing by mTORC1

The FASEB Journal, 2021
openaire   +1 more source

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect [PDF]

, 2011
Mee‐Sup Yoon, Yuting Sun, Edwin Araúz, Yu Jiang, Jie Chen   +4 more
openalex   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Synergistic Inhibition of Prostate Cancer Progression in Mice With a Combination of Curcumin and Ursolic Acid in the Diet

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prostate cancer (PCa) is the second leading cause of cancer‐related death among American men, and its long latency offers a window for chemopreventive strategies. Phytochemicals, with their diverse impacts on cancer cell growth and metabolism, represent promising candidates for such strategies.
Chelsea A. Friedman, Achinto Saha, Rachel Clark, Carly Wilder, Jordan Wright, John DiGiovanni   +5 more
wiley   +1 more source

Comment on 'Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting-Induced Proteolysis' by Espino-Guarch et al. [PDF]

J Cachexia Sarcopenia Muscle
Li J, Peng J.
europepmc   +1 more source

Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis [PDF]

, 2011
Ryota Kurayama, Noriko Ito, Yukino Nishibori, Daisuke Fukuhara, Yoshihiro Akimoto, Eiji Higashihara, Yasuhito Ishigaki, Yoshimichi Sai, Ken–ichi Miyamoto, Hitoshi Endou, Yoshikatstu Kanai, Kunimasa Yan   +11 more
openalex   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source

Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis. [PDF]

Nat Commun
Ehinger Y, Laguesse S, Phamluong K, Salvi A, Sei YJ, Hoisington ZW, Soneja D, Gunasekaran S, Nakamura K, Ron D.   +9 more
europepmc   +1 more source