Results 101 to 110 of about 19,288 (276)

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis [PDF]

, 2017
Autologous haematopoietic stem cell transplantation has been tried as one experimental strategy for the treatment of patients with aggressive multiple sclerosis refractory to other immunotherapies.
Abrahamsson, Sofia V., Angelini, Daniela F., Battistini, Luca, Burt, Richard K., Calabresi, Peter A., Carassiti, Daniele, Coles, Alasdair J., Dubinsky, Amy N., Jones, Joanne L., Martin, Roland, Morel, Esther, Muraro, Paolo A., Oh, Unsong, Reynolds, Richard, Salvetti, Marco   +14 more
core  

Persistent deficiency of mucosal-associated invariant T cells during dermatomyositis

Rheumatology, 2019
Abstract Objectives Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that are important for antibacterial immunity and may have regulatory roles. MAIT cells are decreased during SLE. However, their frequencies and phenotype have not been investigated in DM.
Cassius, Charles, Branchtein, Mylene, Battistella, Maxime, Amode, Reyhan, Lepelletier, Clémence, Jachiet, Marie, de Masson, Adèle, Frumholtz, Laure, Chasset, François, Amoura, Zahir, Mathian, Alexis, Samri, Assia, Monfort, Jean-Benoit, Bachmeyer, Claude, Bengoufa, Djaouida, Cordoliani, Florence, Bagot, Martine, Bensussan, Armand, Bouaziz, Jean-David, Le Buanec, Hélène   +19 more
openaire   +3 more sources

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

The Immunoglobulins of Cold-Blooded Vertebrates [PDF]

, 2014
Peer reviewedPublisher ...
Chen, Clem, Cone, Cooper, Crouch, Deza, Grey, Hadji-Azimi, Hsu, Kokubu, Leslie, Magor, Malecek, Mansikka, Patel, Schaerlinger, Schaerlinger, Small, Steiner, Turchin, Wilson, Wu, Zapata   +22 more
core   +2 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Diverse MR1-restricted T cells in mice and humans

Nature Communications, 2019
Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found ...
Hui-Fern Koay, Nicholas A. Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P. Fairlie, James McCluskey, Daniel G. Pellicci, Adam P. Uldrich, Dale I. Godfrey   +10 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Mucosal-Associated Invariant T Cells Expressing the TRAV1-TRAJ33 Chain Are Present in Pigs

Frontiers in Immunology, 2019
Mucosal-associated invariant T (MAIT) cells are a subpopulation of evolutionarily conserved innate-like T lymphocytes bearing invariant or semi-invariant TCRα chains paired with a biased usage of TCRβ chains and restricted by highly conserved monomorphic
Xingxing Xiao, Xingxing Xiao, Kun Li, Xueting Ma, Xueting Ma, Baohong Liu, Baohong Liu, Xueyang He, Xueyang He, Shunli Yang, Shunli Yang, Wenqing Wang, Wenqing Wang, Baoyu Jiang, Jianping Cai, Jianping Cai   +15 more
doaj   +1 more source

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. [PDF]

, 2020
Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired ...
Ananworanich, Jintanat, Bolton, Diane L, Costanzo, Margaret C, Creegan, Matthew, Dias, Joana, Eller, Leigh Anne, Eller, Michael A, Kibuuka, Hannah, Kim, Dohoon, Kosgei, Josphat, Krebs, Shelly J, Lal, Kerri G, Leeansyah, Edwin, Maganga, Lucas, Michael, Nelson L, Nitayaphan, Sorachai, Paquin-Proulx, Dominic, Phuang-Ngern, Yuwadee, Robb, Merlin L, Sacdalan, Carlo, Sandberg, Johan K, Schuetz, Alexandra, Shacklett, Barbara L, Slike, Bonnie M   +23 more
core