Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins. [PDF]
Mol Cell, 2021 Stracy M +5 more
europepmc +2 more sources
Chromosome dynamics in Bacillus subtilis -Characterization of the Structural Maintenance of Chromosomes (SMC) complex [PDF]
, 2004 Alle Zellen müssen ihr Erbmaterial verdoppeln und dafür Sorge tragen, daß jede Tochterzelle einen kompletten Satz des Erbguts vor der Zellteilung erhält.
Bremer, Erhard, Prof. Dr. +1 more
core +3 more sources
Molecular Microbiology, Volume 114, Issue 5, Page 839-856, November 2020., 2020 The rod‐shaped Myxococcus xanthus cells have a unique chromosome organization whereby the chromosome occupies the central part of cells leaving large subpolar regions devoid of DNA. We show that three systems contribute to chromosome segregation and organization in M.
Deepak Anand +2 more
wiley +1 more source
Dynamic architecture of the Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF. [PDF]
Nucleic Acids Res, 2019 Ubiquitous Structural Maintenance of Chromosomes (SMC) complexes use a proteinaceous ring-shaped architecture to organize and individualize chromosomes, thereby facilitating chromosome segregation.
Rajasekar KV +11 more
europepmc +3 more sources
Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants [PDF]
Journal of Bacteriology, 1995 The partition system of the low-copy-number plasmid/prophage of bacteriophage P1 encodes two proteins, ParA and ParB, and contains a DNA site called parS. ParB and the Escherichia coli protein IHF bind to parS to form the partition complex, in which parS is wrapped around ParB and IHF in a precise three-dimensional conformation.
B E, Funnell, L, Gagnier
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Spo0J and SMC are required for normal chromosome segregation in Staphylococcus aureus
MicrobiologyOpen, Volume 9, Issue 4, April 2020., 2020 Chromosome segregation is an essential but poorly understood process in spherical bacteria such as Staphylococcus aureus. Here, we show that the staphylococcal ParB homologue, Spo0J, and the structural maintenance of chromosomes (SMC) protein act in concert to achieve efficient chromosome segregation in S. aureus. We demonstrate that Spo0J and SMC form
Helena Chan +2 more
wiley +1 more source
Competitive binding of MatP and topoisomerase IV to the MukB dimerization hinge [PDF]
, 2021 ABSTRACTSMC complexes have ubiquitous roles in chromosome organisation. InEscherichia coli,the interplay between the SMC complex, MukBEF, and matS-bound MatP in the replication termination region, ter, results in depletion of MukBEF from ter, thus promoting chromosome individualisation by directing replichores to separate cell halves.
Gemma L. M. Fisher +10 more
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The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion and repair [PDF]
, 2002 The first draft of the human genome sequence was reported a year ago. It may be a good time to remind ourselves that the genetic information encoded in the ∼3000-Mb sequence is stored not only in the public or private databases but also in the tiny space
Hirano, T.
core +1 more source
MukBs cooperate to loop DNA [PDF]
The Journal of Cell Biology, 2008 When it comes to corralling DNA, MukB is the little condensin that could, say Yuanbo Cui, Aoya Petrushenko, and Valentin Rybenkov (University of Oklahoma, Norman, OK). Small in size but with a big effect, condensins are believed to stabilize large DNA loops, thereby giving order to an ...
openaire +1 more source
The MukB-ParC Interaction Affects the Intramolecular, Not Intermolecular, Activities of Topoisomerase IV [PDF]
Journal of Biological Chemistry, 2013 Proper chromosome organization is accomplished through binding of proteins such as condensins that shape the DNA and by modulation of chromosome topology by the action of topoisomerases. We found that the interaction between MukB, the bacterial condensin, and ParC, a subunit of topoisomerase IV, enhanced relaxation of negatively supercoiled DNA and ...
Ryo, Hayama +3 more
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