Results 21 to 30 of about 1,534 (157)
Molecular Microbiology, Volume 114, Issue 5, Page 839-856, November 2020., 2020 The rod‐shaped Myxococcus xanthus cells have a unique chromosome organization whereby the chromosome occupies the central part of cells leaving large subpolar regions devoid of DNA. We show that three systems contribute to chromosome segregation and organization in M.
Deepak Anand +2 more
wiley +1 more source
Competitive binding of MatP and topoisomerase IV to the MukB dimerization hinge [PDF]
, 2021 ABSTRACTSMC complexes have ubiquitous roles in chromosome organisation. InEscherichia coli,the interplay between the SMC complex, MukBEF, and matS-bound MatP in the replication termination region, ter, results in depletion of MukBEF from ter, thus promoting chromosome individualisation by directing replichores to separate cell halves.
Gemma L. M. Fisher +10 more
openaire +1 more source
Spo0J and SMC are required for normal chromosome segregation in Staphylococcus aureus
MicrobiologyOpen, Volume 9, Issue 4, April 2020., 2020 Chromosome segregation is an essential but poorly understood process in spherical bacteria such as Staphylococcus aureus. Here, we show that the staphylococcal ParB homologue, Spo0J, and the structural maintenance of chromosomes (SMC) protein act in concert to achieve efficient chromosome segregation in S. aureus. We demonstrate that Spo0J and SMC form
Helena Chan +2 more
wiley +1 more source
Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Alipour +57 more
core +6 more sources
MukBs cooperate to loop DNA [PDF]
The Journal of Cell Biology, 2008 When it comes to corralling DNA, MukB is the little condensin that could, say Yuanbo Cui, Aoya Petrushenko, and Valentin Rybenkov (University of Oklahoma, Norman, OK). Small in size but with a big effect, condensins are believed to stabilize large DNA loops, thereby giving order to an ...
openaire +1 more source
The MukB-ParC Interaction Affects the Intramolecular, Not Intermolecular, Activities of Topoisomerase IV [PDF]
Journal of Biological Chemistry, 2013 Proper chromosome organization is accomplished through binding of proteins such as condensins that shape the DNA and by modulation of chromosome topology by the action of topoisomerases. We found that the interaction between MukB, the bacterial condensin, and ParC, a subunit of topoisomerase IV, enhanced relaxation of negatively supercoiled DNA and ...
Ryo, Hayama +3 more
openaire +2 more sources
The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion and repair [PDF]
, 2002 The first draft of the human genome sequence was reported a year ago. It may be a good time to remind ourselves that the genetic information encoded in the ∼3000-Mb sequence is stored not only in the public or private databases but also in the tiny space
Hirano, T.
core +1 more source
Chromosome dynamics in Bacillus subtilis -Characterization of the Structural Maintenance of Chromosomes (SMC) complex [PDF]
, 2004 Alle Zellen müssen ihr Erbmaterial verdoppeln und dafür Sorge tragen, daß jede Tochterzelle einen kompletten Satz des Erbguts vor der Zellteilung erhält.
Bremer, Erhard, Prof. Dr. +1 more
core +1 more source
Bacterial Chromosome Organization and Segregation [PDF]
, 2018 If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is ...
Badrinarayanan, Anjana +2 more
core +1 more source
Partitioning of a mini-F plasmid into anucleate cells of the mukB null mutant [PDF]
Journal of Bacteriology, 1991 The partition-proficient mini-F plasmid pXX325 was stably maintained in the mukB null mutant, which is defective in chromosome partitioning into the two daughter cells. In the null mutant, the plasmid was partitioned into both nucleate and anucleate daughter cells, independently of host chromosomes.
B, Ezaki, T, Ogura, H, Niki, S, Hiraga
openaire +2 more sources