Molecular basis for SMC rod formation and its dissolution upon DNA binding. [PDF]
, 2015 SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge" dimerization domain with an ATP-regulated "head ...
Alipour +57 more
core +6 more sources
Interaction of the N‐terminal domain of MukB with the bacterial tubulin homologue FtsZ [PDF]
FEBS Letters, 1998 The MukB protein is involved in the process of chromosome partition in Escherichia coli and has a domain structure reminiscent of the eukaryotic motor proteins kinesin and myosin. This has led to the suggestion that MukB may function as a motor protein in vivo.
Lockhart, Andrew, Kendrick-Jones, John
openaire +2 more sources
Using Fluorescence Recovery After Photobleaching (FRAP) to study dynamics of the Structural Maintenance of Chromosome (SMC) complex in vivo [PDF]
, 2016 The SMC complex, MukBEF, is important for chromosome organization and segregation in Escherichia coli. Fluorescently tagged MukBEF forms distinct spots (or 'foci') in the cell, where it is thought to carry out most of its chromosome associated activities.
A Badrinarayanan +21 more
core +2 more sources
The bacterial condensin MukB compacts DNA by sequestering supercoils and stabilizing topologically isolated loops [PDF]
Journal of Biological Chemistry, 2017 MukB is a structural maintenance of chromosome-like protein required for DNA condensation. The complete condensin is a large tripartite complex of MukB, the kleisin, MukF, and an accessory protein, MukE. As found previously, MukB DNA condensation is a stepwise process. We have defined these steps topologically.
Kumar, R +5 more
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Partitioning of a mini-F plasmid into anucleate cells of the mukB null mutant [PDF]
Journal of Bacteriology, 1991 The partition-proficient mini-F plasmid pXX325 was stably maintained in the mukB null mutant, which is defective in chromosome partitioning into the two daughter cells. In the null mutant, the plasmid was partitioned into both nucleate and anucleate daughter cells, independently of host chromosomes.
B, Ezaki, T, Ogura, H, Niki, S, Hiraga
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Prices and Portfolio Choices in Financial Markets: Theory, Econometrics, Experiments [PDF]
, 2007 Many tests of asset-pricing models address only the pricing predictions, but these pricing predictions rest on portfolio choice predictions that seem obviously wrong.
Bossaerts, Peter +2 more
core +2 more sources
Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction [PDF]
Proceedings of the National Academy of Sciences, 2010 In contrast to the current state of knowledge in the field of eukaryotic chromosome segregation, relatively little is known about the mechanisms coordinating the appropriate segregation of bacterial chromosomes. In Escherichia coli , the MukB/E/F complex and topoisomerase IV (Topo IV) are both crucial players in ...
Yinyin, Li +7 more
openaire +2 more sources
Dynamic nature of SecA and its associated proteins in Escherichia coli.
Frontiers in Microbiology, 2015 Mechanical properties such as physical constraint and pushing of chromosomes are thought to be important for chromosome segregation in Escherichia coli and it could be mediated by a hypothetical molecular tether.
Shun eAdachi +4 more
doaj +1 more source
Bacterial Chromosome Organization and Segregation [PDF]
, 2018 If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long, approximately 1,000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is ...
Badrinarayanan, Anjana +2 more
core +1 more source
Specialized interfaces of Smc5/6 control hinge stability and DNA association [PDF]
, 2017 The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization of higher-order chromosome structure—which is essential for accurate chromosome duplication and segregation.
A Chiu +65 more
core +1 more source