Results 31 to 40 of about 25,566 (261)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Prognostics-aware multi-robot route planning to extend the lifetime
Kuwait Journal of Science, 2022 Transformation to Industry 4.0, manufacturing needs more intelligent systems with capable of selfawareness. Self-awareness is becoming reality to extend classical manufacturing systems to digital.
Ugur Yayan, Ahmet Yazici, Inci SARICICEK
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
MachinesIn this paper, an adaptive and resilient consensus control mechanism for multi-robot systems under Byzantine attack, based on sliding mode control, is proposed. The primary aim of the article is to develop a finite-time consensus control strategy even in
Muhammad Nasir, Ananda Maiti
doaj +1 more source
Interaction Templates for Multi-Robot Systems [PDF]
IEEE Robotics and Automation Letters, 2019 This letter describes a framework for multi-robot problems that require or utilize interactions between robots. Solutions consider interactions on a motion planning level to determine the feasibility and cost of the multi-robot team solution. Modeling these problems with current integrated task and motion planning (TMP) approaches typically requires ...
James Motes +5 more
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Robotic Systems of Systems Based on a Decentralized Service-Oriented Architecture
Robotics, 2020 Multi-robot systems are often static and pre-configured during the design time of their software. Emerging cooperation between unknown robots is still rare and limited.
Lennart Siefke +3 more
doaj +1 more source
Learning in multi-robot systems
, 1996 This paper discusses why traditional reinforcement learning methods often result in poor performance in dynamic, situated multiagent domains characterized by multiple goals, noisy perception and action, and inconsistent reinforcement. We propose a methodology for designing the representation and the forcement functions that take advantage of implicit ...
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source