Results 211 to 220 of about 262,601 (237)

Multidrug efflux pumps of Gram-positive bacteria

Drug Resistance Updates, 2016
Gram-positive organisms are responsible for some of the most serious of human infections. Resistance to front-line antimicrobial agents can complicate otherwise curative therapy. These organisms possess multiple drug resistance mechanisms, with drug efflux being a significant contributing factor.
Bryan D, Schindler, Glenn W, Kaatz
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Assessing the Activity of Bacterial Multidrug Efflux Pumps

2003
Resistance to antibiotics in target bacterial populations has long complicated antibacterial chemotherapy. First described in the early 1980s (1, 2), efflux mechanism of resistance, whereby the antibiotic is actively (i.e., in an energy-dependent fashion) pumped from the bacterial cell, are being described with increasing frequency in recent years ...
K, Poole, R, Srikumar
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Transcriptional regulation of multidrug efflux pumps in bacteria

Seminars in Cell & Developmental Biology, 2001
As integral membrane proteins demonstrating an extraordinarily wide substrate range, some degree of regulatory control over the expression of bacterial multidrug-resistance (MDR) transporters is to be expected. Excessive expression could be deleterious, due to direct, physical disruption of membrane integrity, or the unwanted export of essential ...
S, Grkovic, M H, Brown, R A, Skurray
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Multidrug efflux pumps and resistance: regulation and evolution

Current Opinion in Microbiology, 2003
Multidrug transporters have long puzzled researchers because of their ability to extrude multiple structurally dissimilar toxic chemotherapeutic agents. They appear to be essentially ubiquitous with many microorganisms possessing large arsenals of predicted multidrug efflux transporters. Recent reports on the structures of multidrug efflux transporters
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Multidrug efflux transporter, AcrB—the pumping mechanism

Current Opinion in Structural Biology, 2008
Resistance nodulation cell division (RND) transporters are one of the main causes of the bacterial multidrug resistance. They pump a wide range of antibiotics out of the cell by proton motive force. AcrB is the major RND transporter in Escherichia coli. Recently, the crystal structures of AcrB have been determined by different space groups.
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Multidrug efflux pumps: Substrate selection in ATP‐binding cassette multidrug efflux pumps – first come, first served?

The FEBS Journal, 2010
Multidrug resistance is a major challenge in the therapy of cancer and pathogenic fungal infections. More than three decades ago, P‐glycoprotein was the first identified multidrug transporter. It has been studied extensively at the genetic and biochemical levels ever since.
Robert, Ernst, Petra, Kueppers, Jan, Stindt, Karl, Kuchler, Lutz, Schmitt   +4 more
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Optimized efflux assay for the NorA multidrug efflux pump in Staphylococcus aureus

Journal of Microbiological Methods, 2017
Real-time fluorescent efflux assays are commonly used for measuring the efflux of bacterial pumps. Here we describe an optimized protocol for the NorA efflux pump in S. aureus using DiOC3 instead of ethidium bromide. Glucose and sodium formate were tested as energy carriers. This novel method is fast and reproducible.
Saskia, Zimmermann, Lorena, Tuchscherr, Jürgen, Rödel, Bettina, Löffler, Jürgen A, Bohnert   +4 more
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Multidrug Efflux Pumps in the Genus Erwinia: Physiology and Regulation of Efflux Pump Gene Expression

2016
Plant pathogens belonging to the genus Erwinia cause diseases in several economically important plants. Plants respond to bacterial infection with a powerful chemical arsenal and signaling molecules to rid themselves of the microbes. Although our understanding of how Erwinia initiate infections in plants has become clear, a comprehensive understanding ...
J, Thekkiniath, R, Ravirala, M, San Francisco   +2 more
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Small Multidrug Resistance Efflux Pumps

2016
Small multidrug resistance (SMR) transporters confer resistance to a variety of quaternary cation compound antimicrobials. These secondary active transporters are the smallest known transporters and have been demonstrated to function within the membrane.
Denice C. Bay, Raymond J. Turner
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Assembly and operation of bacterial tripartite multidrug efflux pumps

Trends in Microbiology, 2015
Microorganisms encode several classes of transmembrane pumps that can expel an enormous range of toxic substances, thereby improving their fitness in harsh environments and contributing to resistance against antimicrobial agents. In Gram-negative bacteria these pumps can take the form of tripartite assemblies that actively efflux drugs and other ...
Dijun, Du, Hendrik W, van Veen, Ben F, Luisi   +2 more
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