Results 201 to 210 of about 262,601 (237)

Tetracyclines, a timely resurgence or doomed to fail again? [PDF]

J Med Microbiol
Fenn S, Panagiotopoulou D, Hardie KR.
europepmc   +1 more source

Exploring allosteric efflux pump inhibitors and the role of bacterial membrane potential in modulating drug resistance. [PDF]

Front Microbiol
Hada APS, Meena KR, Jitendra, Singh G, Arya H, Kumar A.   +5 more
europepmc   +1 more source

<i>Stenotrophomonas maltophilia</i> in the Antimicrobial Resistance Era: Species-Complex Taxonomy, Pathogenesis, Evolving Therapeutic Priorities, and Genomic Surveillance. [PDF]

Infect Drug Resist
Sun R, Cao X, Sun Q.
europepmc   +1 more source

Detection of carbapenem resistance mechanisms in difficult-to-treat Pseudomonas aeruginosa clinical isolates from a tertiary care hospital in Egypt. [PDF]

BMC Microbiol
Salem D, Zaiton M, El-Shenawy A, Dahroug H, El-Dein S, Gamal D, Althoqapy AA, Mohamed AA, Shemis MA, Diab M, Maklad SS.   +10 more
europepmc   +1 more source

10d, a Pyridoquinoxaline-Based P-Glycoprotein Inhibitor, Exacerbates MPTP-Induced Neurotoxicity in PC12 Cells. [PDF]

Curr Issues Mol Biol
Cannas C, Rocchitta G, Carta A, Piras S, Migheli R.   +4 more
europepmc   +1 more source

Nonantibiotic-driven evolution reveals rare but predictable routes to broad antibiotic resistance. [PDF]

mBio
Li C, Mitchell A.
europepmc   +1 more source

Multidrug efflux pumps: structure, function and regulation [PDF]

Nature Reviews Microbiology, 2018
Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to ...
Klaas M Pos, Dijun Du, Xuan Wang-Kan
exaly   +5 more sources

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Inhibition of the multidrug resistance efflux pump

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1993
An ATP-dependent efflux pump is found in the plasma membrane of certain multidrug resistant (MDR) cancer cells. Drug resistance is due to decreased intracellular drug levels that have been reduced to subcytotoxic concentrations. Inhibition of the MDR efflux pump with a reversal agent may 'trap' the cytotoxic drug inside the cell; thus, cellular drug ...
P W, Wigler, F K, Patterson
openaire   +2 more sources

Multidrug efflux pumps in Staphylococcus aureus and their clinical implications

Journal of Microbiology, 2016
Antibiotic resistance is rapidly spreading among bacteria such as Staphylococcus aureus, an opportunistic bacterial pathogen that causes a variety of diseases in humans. For the last two decades, bacterial multidrug efflux pumps have drawn attention due to their potential association with clinical multidrug resistance.
Soojin Jang
exaly   +3 more sources

Towards understanding promiscuity in multidrug efflux pumps

Trends in Biochemical Sciences, 2014
Drug export from cells is a major factor in the acquisition of cellular resistance to antimicrobial and cancer chemotherapy, and poses a significant threat to future clinical management of disease. Many of the proteins that catalyse drug efflux do so with remarkably low substrate specificity, a phenomenon known as multidrug transport. For these reasons
Kelvin, Wong, Jerome, Ma, Alice, Rothnie, Philip C, Biggin, Ian D, Kerr   +4 more
openaire   +2 more sources