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Multidrug Efflux Pumps Attenuate the Effect of MGMT Inhibitors
Molecular Pharmaceutics, 2015Various mechanisms of drug resistance attenuate the effectiveness of cancer therapeutics, including drug transport and DNA repair. The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is a key factor determining the resistance against alkylating anticancer drugs inducing the genotoxic DNA lesions O(6)-methylguanine and O(6 ...
Karl-Heinz, Tomaszowski +2 more
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Antibiotics: Pharmacokinetics, toxicity, resistance and multidrug efflux pumps
Biochemical Pharmacology, 2017The discovery of penicillin followed by streptomycin, tetracycline, cephalosporins and other natural, semi-synthetic and synthetic antimicrobials completely revolutionized medicine by reducing human morbidity and mortality from most of the common infections. However, shortly after they were introduced to clinical practice, the development of resistance
Çiğdem, Yılmaz, Gülay, Özcengiz
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Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes
Biochemical and Biophysical Research Communications, 2005Chloramphenicol has been reported to act as an inducer of the multidrug resistance in Escherichia coli. A resistant variant able to grow on plates containing 64 microg/ml chloramphenicol was obtained from the Enterobacter aerogenes ATCC 13048-type strain.
Didier, Ghisalberti +3 more
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Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes
Biochemical and Biophysical Research Communications, 2003Imipenem is often used to treat intensive care unit patients infected by Enterobacter aerogenes, but it is leading to an increasing number of antibiotic resistant strains. Clinical isolates and imipenem resistant variants presented a high level of resistance to beta-lactam antibiotic group and to chemically unrelated drugs. We report here that imipenem
Charléric, Bornet +6 more
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Update on Multidrug Resistance Efflux Pumps in Acinetobacter spp.
Antimicrobial Agents and Chemotherapy, 2021Ayush Kumar, Vanessa Kornelsen
exaly
Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials
Drug Resistance Updates, 2016Sara Hernando-Amado +2 more
exaly
Multidrug-resistance efflux pumps ? not just for resistance
Nature Reviews Microbiology, 2006Laura Piddock
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