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An Fc Binding Peptide-Based Facile and Versatile Build Platform for Multispecific Antibodies
Nano Letters, 2023 Multispecific antibodies (MsAbs) maintain the specificity of versatile antibodies while simultaneously addressing different epitopes for a cumulative, collaborative effect.
Junli Hu, Changlu Shao, Haochen Yao
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Molecular imaging supports the development of multispecific cancer antibodies [PDF]
Nature Reviews Clinical OncologyMultispecific antibodies are engineered antibody derivatives that can bind to two or more distinct epitopes or antigens. Unlike mixtures of monospecific antibodies, the binding properties of multispecific antibodies enable two specific molecules to be ...
Marjolijn N Lub-de Hooge +1 more
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Multispecific monoclonal antibodies
Immunology Today, 1986Monoclonal antibodies are frequently shown to participate in unexpected cross reactions involving two apparently dissimilar antigens. This can be attributed either to partial epitope identity or to irrelevant interactions involving additional binding capacity of the antibody.
D, Isenberg, C, Dudeney, W, Williams
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Evidence for multispecificity of antibody molecules
Nature, 1977ONE of the salient questions in immunology concerns the means by which the immune system is capable of recognising an apparently limitless variety of antigenic determinants, including many that presumably did not exist during its evolution. Three major hypotheses have been put forward to explain the diversity of the immune response: a stringent germ ...
D J, Cameron, B F, Erlanger
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Expression of Multispecific Antibodies
Bi- and multispecific antibody formats allow the development of new therapeutic strategies to address previously unmet medical needs. However, due to the increased complexity (e.g., the interface design and the presence of multiple binders), such molecules are generally more challenging to express and purify compared to standard monoclonal antibodies ...Megane, Peltret +5 more
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Antibody multispecificity in immunoassay interference
Clinical Biochemistry, 1992Recent findings indicate that many endogenous antibodies exhibit multispecificity. These antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere with immunoassays have been called heterophile or heterophilic antibodies.
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