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Towards Multispecific Anti‐Gp120 Artificial Antibody
ChemMedChemBroadly neutralizing antibodies are potential therapeutic drugs that can recognize and block viral entry. But many viruses, such as human immunodeficiency virus (HIV), mutate rapidly and thus evade therapeutic antibodies. Multispecific antibodies and combinations of different antibodies can effectively suppress immune evasion.
Yiwei Sun +4 more
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European Journal of Immunology, 1988
AbstractThe five selections carried out in the mouse for high or low antibody responsiveness to various multideterminant immunogens were successful. In all cases the large interline difference was shown to result from the additive effects of several independently segregating loci (polygenic regulation).
Denise Mouton +10 more
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AbstractThe five selections carried out in the mouse for high or low antibody responsiveness to various multideterminant immunogens were successful. In all cases the large interline difference was shown to result from the additive effects of several independently segregating loci (polygenic regulation).
Denise Mouton +10 more
openaire +2 more sources
Generation of Multispecific Antibodies with Immune Cell Modulating Functions
2023Within the field of biologics, monoclonal antibodies have ruled the market with blockbuster and top selling drugs over the last decades. With the advancements in technological discoveries, lightspeed progress has been achieved to discover novel antibodies and mechanisms of action to address unmet needs and indications.
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Multispecific Antibodies Targeting PD-1/PD-L1 in Cancer
BioDrugsThe development of immune checkpoint inhibitors has revolutionized the treatment of patients with cancer. Targeting the programmed cell death protein 1 (PD-1)/programmed cell death 1 ligand 1(PD-L1) interaction using monoclonal antibodies has emerged as a prominent focus in tumor therapy with rapid advancements. However, the efficacy of anti-PD-1/PD-L1
Miaomiao Chen +5 more
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[Propylthiouracil-induced multispecific antineutrophil cytoplasmic antibodies].
La Revue de medecine interne, 2011We report the case of a 28-year-old woman who presented with arthralgia during a treatment with propylthiouracil (PTU) for hyperthyroidism. Detection of antineutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase, proteinase 3 and elastase led to suspect PTU induced vasculitis.
A, Servonnet +4 more
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Multispecific anti neutrophil cytoplasm antibodies: a case report.
La Tunisie medicale, 2012To report the presence af ANCA with an unusual polyreactivity.50 year-old woman with pulmonary fibrosis whose immunological investigations showed the presence of ANCA with an unusual polyreactivity against several neutrophil proteins (PR3,MPO, BPI, lysozyme, elastase and cathepsine G) which could be related to a polyclonal hypergammaglobulinemia ...
Marouane, Haddad +7 more
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An Fc Binding Peptide-Based Facile and Versatile Build Platform for Multispecific Antibodies
Nano Letters, 2023Haochen Yao, Changlu Shao, Na Shen
exaly
Multispecific recognition of allergens by IgE antibodies
Journal of Molecular Recognition, 1995J. M. Varga +3 more
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Bispecific, Multispecific Antibodies Grapple with Cancer
Genetic Engineering & Biotechnology News, 2019openaire +1 more source
Regulatory Influences of Neonatal Multispecific Antibodies on the Developing B Cell Repertoire
International Reviews of Immunology, 1988Meenal Vakil, John F Kearney, M Vakil
exaly