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Evidence for multispecificity of antibody molecules
Nature, 1977ONE of the salient questions in immunology concerns the means by which the immune system is capable of recognising an apparently limitless variety of antigenic determinants, including many that presumably did not exist during its evolution. Three major hypotheses have been put forward to explain the diversity of the immune response: a stringent germ ...
D J, Cameron, B F, Erlanger
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Rationale and development of multispecific antibody drugs
Expert Review of Clinical Pharmacology, 2010Bispecific antibodies (bsAbs) have been on the scene for decades and represent the next generation of antibody-based therapeutics. Unlike monospecific, monoclonal antibodies (mAbs), bsAbs can target two or more disease mechanisms as a single agent and can offer certain unique therapeutic strategies that are difficult to acheive with mAbs.
Jijie, Gu, Tariq, Ghayur
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Molecular imaging supports the development of multispecific cancer antibodies
Nature Reviews Clinical OncologyMultispecific antibodies are engineered antibody derivatives that can bind to two or more distinct epitopes or antigens. Unlike mixtures of monospecific antibodies, the binding properties of multispecific antibodies enable two specific molecules to be physically linked, a characteristic with important applications in cancer therapy.
Claudia A J Van Winkel +2 more
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Are Cross-Reacting Natural Antibodies Multispecific?
International Archives of Allergy and Applied Immunology, 2009Human natural antibodies to antigens of Escherichia coli and Serratia marcescens were studied for cross-reactivity. The organisms were grown on synthetic media and extracted at lOO°C. The extracts were precipitated three times at 71% ethanol concentration and redissolved at the desired concentration.
F, Milgrom, Z, Swierczynska
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Elucidating the Mechanism of Multispecific Antibody Aggregation through Subunit Analysis
Journal of the American Society for Mass Spectrometry, 2023Multispecific antibody constructs are quickly becoming more common constructs in biopharmaceuticals to improve specificity and efficacy. While the advent of this technology has led to improved therapeutics, its development has challenged the analytical tools through which these therapeutics are characterized.
Michael L. Poltash +7 more
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Antibody multispecificity in immunoassay interference
Clinical Biochemistry, 1992Recent findings indicate that many endogenous antibodies exhibit multispecificity. These antibodies exhibit a potential for interference with immunoassays. Antibodies that interfere with immunoassays have been called heterophile or heterophilic antibodies.
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Natural DNP-binding immunoglobulins and antibody multispecificity
Molecular Immunology, 1984Anti-DNP activity was found in normal human immunoglobulins with average affinities (10(4)-10(6) l/mole) and frequencies (15-2%) that correlate well with those expected from multispecific binding sites.
E, Ortega, M, Kostovetzky, C, Larralde
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Expression of Multispecific Antibodies
Bi- and multispecific antibody formats allow the development of new therapeutic strategies to address previously unmet medical needs. However, due to the increased complexity (e.g., the interface design and the presence of multiple binders), such molecules are generally more challenging to express and purify compared to standard monoclonal antibodies ...Megane, Peltret +5 more
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Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease Treatment
Annual Review of Chemical and Biomolecular EngineeringAntibody-based therapeutics constitute a rapidly growing class of pharmaceutical compounds. However, monoclonal antibodies, which specifically engage only one target, often lack the mechanistic intricacy to treat complex diseases. To expand the utility of antibody therapies, significant efforts have been invested in designing multispecific antibodies ...
Jamie B Spangler
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Bispecific and multispecific antibodies in oncology: opportunities and challenges
Nature Reviews Clinical OncologyResearch into bispecific antibodies, which are designed to simultaneously bind two antigens or epitopes, has advanced enormously over the past two decades. Owing to advances in protein engineering technologies and considerable preclinical research efforts, bispecific antibodies are constantly being developed and optimized to improve their efficacy and ...
Maria-Elisabeth Goebeler +2 more
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