Results 1 to 10 of about 133,873 (236)

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +3 more sources

Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear

Frontiers in Neuroscience, 2021
Stimulation of cholinergic efferent neurons innervating the inner ear has profound, well-characterized effects on vestibular and auditory physiology, after activating distinct ACh receptors (AChRs) on afferents and hair cells in peripheral endorgans ...
Choongheon Lee, Anjali K. Sinha, Kenneth Henry, Kenneth Henry, Anqi W. Walbaum, Peter A. Crooks, Joseph C. Holt, Joseph C. Holt, Joseph C. Holt   +8 more
doaj   +1 more source

Effect of Agonist and Antagonist on the In Vitro Contractility of Inflamed Vermiform Appendix [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Appendicitis poses a great health problem worldwide. Previous studies demonstrated structural damage to neuronal network and interstitial cell of Cajal in appendicitis.
Phani Bhushan Singh, Pushpakant Tiwary, Sanjeev K Singh, Ratna Pandey, Atanu Roy, Amrita Ghosh Kar, Somprakas Basu, Anil Kumar Tiwari   +7 more
doaj   +1 more source

A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity

Pharmaceutics, 2023
Anticholinergic burden tools have relevant pharmacological gaps that may explain their limited predictive ability for clinical outcomes. The aim of this study was to provide a universal pharmacological-based list of drugs with their documented affinity ...
Marta Lavrador, Ana C. Cabral, Manuel T. Veríssimo, Fernando Fernandez-Llimos, Isabel V. Figueiredo, M. Margarida Castel-Branco   +5 more
doaj   +1 more source

Aqueous Tuber Extracts of Tylosema fassoglense (Kotschy ex Schweinf.) Torre and Hillc. (Fabaceae). Possess Significant In-Vivo Antidiarrheal Activity and Ex-Vivo Spasmolytic Effect Possibly Mediated by Modulation of Nitrous Oxide System, Voltage-Gated Calcium Channels, and Muscarinic Receptors

Frontiers in Pharmacology, 2021
Tylosema fassoglense (TFG) is used as an antidiarrheal traditional medicine in Western Kenya. This study aimed to investigate the antidiarrheal activity of its aqueous extracts in-vivo and the putative mechanism (s) of action ex-vivo using Sprague-Dawley
Washika Amos Mapesa, Mwangi Peter Waweru, Frederick Bukachi, Kayaja David Wafula   +3 more
doaj   +1 more source

Acetylcholine regulation of GnRH neuronal activity: A circuit in the medial septum

Frontiers in Endocrinology, 2023
In vertebrates, gonadotropin-releasing hormone (GnRH)-secreting neurons control fertility by regulating gonadotrophs in the anterior pituitary. While it is known that acetylcholine (ACh) influences GnRH secretion, whether the effect is direct or indirect,
David M. Shostak, Stephanie Constantin, Jill Flannery, Susan Wray   +3 more
doaj   +1 more source

Allosteric modulation in monomers and oligomers of a G protein-coupled receptor

eLife, 2016
The M2 muscarinic receptor is the prototypic model of allostery in GPCRs, yet the molecular and the supramolecular determinants of such effects are unknown.
Rabindra V Shivnaraine, Brendan Kelly, Krishana S Sankar, Dar'ya S Redka, Yi Rang Han, Fei Huang, Gwendolynne Elmslie, Daniel Pinto, Yuchong Li, Jonathan V Rocheleau, Claudiu C Gradinaru, John Ellis, James W Wells   +12 more
doaj   +1 more source

Muscarinic receptor oligomerization [PDF]

Neuropharmacology, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins. However, in recent years, a growing number of studies has supported the hypothesis that these receptors can interact to form dimers and higher order oligomers
Marsango, Sara, Ward, Richard J., Alvarez-Curto, Elisa, Milligan, Graeme   +3 more
openaire   +2 more sources

Scopolamine Reduces Electrophysiological Indices of Distractor Suppression: Evidence from a Contingent Capture Task

Frontiers in Neural Circuits, 2017
Limited resources for the in-depth processing of external stimuli make it necessary to select only relevant information from our surroundings and to ignore irrelevant stimuli.
Inga Laube, Inga Laube, Natasha Matthews, Angela J. Dean, Redmond G. O’Connell, Redmond G. O’Connell, Jason B. Mattingley, Mark A. Bellgrove, Mark A. Bellgrove   +8 more
doaj   +1 more source

Presencia de anticuerpos contra neurorreceptores cardiacos de acetilcolina muscarínicos tipo II en pacientes con enfermedad de Chagas e implantación de marcapasos

Biomédica: revista del Instituto Nacional de Salud, 2009
Introducción. En diferentes tipos de afecciones cardiacas, incluida la enfermedad de Chagas, se ha descrito la presencia de anticuerpos que reconocen neurorreceptores cardiacos.
María Clara Echeverry, Nubia Catalina Tovar, Guillermo Mora   +2 more
doaj   +1 more source