Results 131 to 140 of about 30,424 (296)

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors [PDF]

, 2018
Positive allosteric modulators (PAMs) that target the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer's disease and schizophrenia.
Andrew B. Tobin, Arthur Christopoulos, Arthur Spathis, Ben Capuano, Celine Valant, Davoren, Ehlert, Ehlert, Elham Khajehali, Emma T. van der Westhuizen, Furchgott, Manuela Jörg, Mistry, Patrick M. Sexton, Peter J. Scammells, Shailesh N. Mistry   +15 more
core   +2 more sources

Binding and functional characterisation of allosteric agonists at M2 muscarinic acetylcholine receptors

The FASEB Journal, 2008
Muscarinic acetylcholine receptors (mAChRs) contain at least one allosteric site that is topographically distinct from the acetylcholine (ACh)‐binding orthosteric site. Although numerous studies have investigated the structural basis of allosteric modulation at these receptors, far less is known about allosteric ligands that ...
Karen Joan Gregory, Nathan E. Hall, Patrick M. Sexton, Arthur Christopoulos   +3 more
openaire   +1 more source

Novel long-range inhibitory nNOS-expressing hippocampal cells

eLife, 2019
The hippocampus, a brain region that is important for spatial navigation and episodic memory, benefits from a rich diversity of neuronal cell-types. Through the use of an intersectional genetic viral vector approach in mice, we report novel hippocampal ...
Zoé Christenson Wick, Madison R Tetzlaff, Esther Krook-Magnuson   +2 more
doaj   +1 more source

The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation [PDF]

, 2005
Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal ...
Christ, T., Dobrev, D., Friedrich, A., Jost, Norbert, Knaut, M., Ravens, U., Voigt, N., Wettwer, E.   +7 more
core   +1 more source

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The development of selective antagonists for muscarinic acetylcholine receptors is challenging due to high homology in orthosteric binding sites among subtypes.
Hongtao Liu, J. Hofmann, I. Fish, B. Schaake, K. Eitel, A. Bartuschat, J. Kaindl, H. Rampp, A. Banerjee, H. Hübner, M. Clark, S. Vincent, J. Fisher, M. Heinrich, K. Hirata, Xiangyu Liu, R. Sunahara, B. Shoichet, B. Kobilka, P. Gmeiner   +19 more
semanticscholar   +1 more source

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

M2 muscarinic receptor activation regulates schwann cell differentiation and myelin organization [PDF]

, 2014
Glial cells express acetylcholine receptors. In particular, rat Schwann cells express different muscarinic receptor subtypes, the most abundant of which is the M2 subtype. M2 receptor activation causes a reversible arrest of the cell cycle. This negative
Arthur-Farraj, Arthur-Farraj, Barlow, Bernardini, Birchmeier, Brockes, Corsetti, Davis, De Angelis, De Felipe, Doddrell, Ebihara, Fernandez-Valle, Ferretti, Fields, Fontana, Grando, Jessen, Jessen, Jessen, Kammer, Kawashima, Kim, LeBlanc, LeBlanc, Li, Livak, Loreti, Loreti, Magnaghi, Magnaghi, Mayhew, Mirsky, Monje, Morgan, Murphy, Parkinson, Peirano, Procacci, Proskocil, Ragheb, Rangarajan, Salani, Shy, Stevens, Stewart, Svaren, Syed, Taveggia, Topilko, Tricaud, Woodhoo, Woodhoo   +52 more
core   +4 more sources

Internalization of the m2 Muscarinic Acetylcholine Receptor [PDF]

Journal of Biological Chemistry, 1997
Robin Pals-Rylaarsdam, Vsevolod V. Gurevich, Katharine B. Lee, Judith A. Ptasienski, Jeffrey L. Benovic, M. Marlene Hosey   +5 more
openaire   +1 more source

Slow synaptic transmission in frog sympathetic ganglia [PDF]

, 1986
Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs.
Adams, P. R., Brown, D. A., Jones, S. W., Koch, Christof, Lancaster, B., Pennefeather, P.   +5 more
core   +2 more sources

Molecular mechanisms for fetal cardiac arrhythmia in intrahepatic cholestasis of pregnancy

, 2010
Intrahepatic cholestasis in pregnancy (ICP) is characterized by raised serum bile acids which can cause fetal complications, including preterm labour and intrauterine death. The fetal death in ICP is not well understood. In this thesis, the mechanisms of
Sheikh Abdul Kadir, Siti Hamimah, Sheikh Abdul Kadir, Siti Hamimah   +1 more
core   +1 more source