Results 11 to 20 of about 436,421 (289)

Vascular smooth muscle contraction in hypertension [PDF]

Cardiovascular Research, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +6 more sources

Guidance Molecules in Vascular Smooth Muscle [PDF]

Frontiers in Physiology, 2018
Several highly conserved families of guidance molecules, including ephrins, Semaphorins, Netrins, and Slits, play conserved and distinct roles in tissue remodeling during tissue patterning and disease pathogenesis.
Alexandra Christine Finney, Anthony Wayne Orr, Anthony Wayne Orr, Anthony Wayne Orr   +3 more
doaj   +4 more sources

EPAC in Vascular Smooth Muscle Cells [PDF]

International Journal of Molecular Sciences, 2020
Vascular smooth muscle cells (VSMCs) are major components of blood vessels. They regulate physiological functions, such as vascular tone and blood flow. Under pathological conditions, VSMCs undergo a remodeling process known as phenotypic switching. During this process, VSMCs lose their contractility and acquire a synthetic phenotype, where they over ...
Firas Kobeissy, Alessandra Bitto, Suzanne A. Nasser, Nadine Wehbe, Rabah Iratni, Elias Baydoun, Adnan Badran, Ali H. Eid, Ali H. Eid, Yusra Al-Dhaheri, Ahmed F. El-Yazbi   +10 more
openaire   +3 more sources

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel, Ricardo Espinosa-Tanguma, Madeline Nieves-Cintron, Manuel F. Navedo   +3 more
doaj   +1 more source

Differentiation of multipotent vascular stem cells contributes to vascular diseases. [PDF]

, 2012
It is generally accepted that the de-differentiation of smooth muscle cells, from the contractile to the proliferative/synthetic phenotype, has an important role during vascular remodelling and diseases.
Chu, Julia S, Helms, Jill A, Li, Song, Liu, Bo, Tang, Zhenyu, Wang, Aijun, Yan, Zhiqiang, Yuan, Falei   +7 more
core   +1 more source

iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. [PDF]

PLoS ONE, 2012
Calcium independent group VIA phospholipase A(2) (iPLA(2)β) is up-regulated in vascular smooth muscle cells in some diseases, but whether the up-regulated iPLA(2)β affects vascular morphology and blood pressure is unknown.
Lindsay E Calderon, Shu Liu, Wen Su, Zhongwen Xie, Zhenheng Guo, Wanda Eberhard, Ming C Gong   +6 more
doaj   +1 more source

Acute glucose influx-induced mitochondrial hyperpolarization inactivates myosin phosphatase as a novel mechanism of vascular smooth muscle contraction

Cell Death and Disease, 2021
It is well-established that long-term exposure of the vasculature to metabolic disturbances leads to abnormal vascular tone, while the physiological regulation of vascular tone upon acute metabolic challenge remains unknown.
Jie Xu, Hongyan Yang, Lu Yang, Zhen Wang, Xinghua Qin, Jiaheng Zhou, Ling Dong, Jia Li, Minsheng Zhu, Xing Zhang, Feng Gao   +10 more
doaj   +1 more source

Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders [PDF]

, 2016
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases ...
Aggarwal, M., Brozovich, F. V., Degen, C. V., Gao, Yuan Z., Morgan, K. G., Nicholson, C. J.   +5 more
core   +1 more source

α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies

Brazilian Journal of Cardiovascular Surgery, 2015
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse
Shi-Min Yuan
doaj   +1 more source

Vascular smooth muscle Sirtuin-1 protects against aortic dissection during Angiotensin II-induced hypertension [PDF]

, 2015
BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not ...
Akiki, Rachid, Bachschmid, Markus, Cohen, Richard A., Fry, Jessica L., Gao, Yuan Z., Morgan, Kathleen G., Seta, Francesca, Shiraishi, Yasunaga, Turcotte, Raphaël, Yu, Xunjie, Zhang, Yanhang   +10 more
core   +1 more source