Results 61 to 70 of about 436,421 (289)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Spontaneous contractile dynamics of the vascular smooth muscle of the external carotid artery

Medisan, 2021
Introduction: The external carotid is a muscle artery irrigating all components of the masticatory system, so that the regulation of the contractile dynamics of its vascular smooth muscle is important.
Oscar Rodríguez Reyes, Thomas K. Noack, Robert Patejdl, Ramón Enrique García Rodríguez   +3 more
doaj  

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.

PLoS Genetics, 2019
As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston, Lei Zeng, Abidemi Onabadejo, Sarah J Childs   +3 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins [PDF]

, 2015
Vascular pathologies are associated with changes in the presence and expression of morphologically distinct vascular smooth muscle cells. In particular, in complex human vascular lesions and models of disease in pigs and rodents, an intimal smooth muscle
Arnold, Askari, Askari, Askari, Bishop-Bailey, Bishop-Bailey, Bishop-Bailey, Bishop-Bailey, Bishop-Bailey, Brisset, Bruce D. Hammock, Bystrom, Capdevila, Darryl C. Zeldin, David Bishop-Bailey, Deng, Derek Gilroy, Feil, Fischer, Fleming, Fred B. Lih, Hao, Hao, Hao, Harris, Imig, Lemire, Majesky, Majesky, Matthew L. Edin, Michael Davies, Muhammad M. Yaqoob, Myit, Neuville, Piqueras, Renton, Schuchardt, Scott Thomson, Shanahan, Spiecker, Thomson, Villaschi, Westphal, Wray, Yan, Zeldin, Zhang   +46 more
core   +2 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4

Redox Biology, 2022
Prevention of phenotype switching of vascular smooth muscle cells is an important determinant of normal vascular physiology. Hydrogen peroxide (H2O2) promotes osteogenic differentiation of vascular smooth muscle cells through expression of Runt related ...
Kai er Ying, Wenguang Feng, Wei-Zhong Ying, Xingsheng Li, Dongqi Xing, Yong Sun, Yabing Chen, Paul W. Sanders   +7 more
doaj  

Endothelial and smooth muscle cell interactions with a PCL-PU composite vascular scaffold with potential for bioactive release [PDF]

, 2006
Paper discussing endothelial and smooth muscle cell interactions with a PCL-PU composite vascular scaffold with potential for bioactive ...
Black, Richard, Kielty, Cay, Williamson, Matthew R.   +2 more
core  

Hypoxia, vascular smooth muscles and endothelium

Acta Pharmaceutica Sinica B, 2013
AbstractHypoxia, or the lack of oxygen, has multiple impacts on the vascular system. The major molecular sensors for hypoxia at the cellular level are hypoxia inducible factor and heme oxygenase. Hypoxia also acts on the vasculature directly conveying its damaging effects through disruption of the control of vascular tone, particularly in the coronary ...
Paul M. Vanhoutte, Paul M. Vanhoutte, Calvin Kiu Yan Chan   +2 more
openaire   +3 more sources