A non-apoptotic role for caspase-9 in muscle differentiation [PDF]
, 2008 Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation.
Fearnhead, Howard O +7 more
core +1 more source
Frontiers in Genetics, 2019 Long noncoding RNAs (lncRNAs) have emerged as essential regulators of skeletal myogenesis, but few myogenesis-associated lncRNAs have been identified and our understanding of their regulatory mechanisms remains limited, particularly in goat.
Siyuan Zhan +12 more
doaj +1 more source
New insights into the epigenetic control of satellite cells [PDF]
, 2015 Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio +2 more
core +1 more source
Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy [PDF]
, 2020 Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility due to high-fat diets contributing to obesity and type 2 diabetes.
Andújar, Eloísa +7 more
core +1 more source
Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation
Nature Communications, 2023 Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells.
Marlies Cortés +17 more
doaj +1 more source
Circular RNA circMYBPC1 promotes skeletal muscle differentiation by targeting MyHC
Molecular Therapy: Nucleic Acids, 2021 Skeletal muscle development is a complex and highly orchestrated biological process mediated by a series of myogenesis regulatory factors. Numerous studies have demonstrated that circular RNAs (circRNAs) are involved in muscle differentiation, but the ...
Mengjie Chen +8 more
doaj +1 more source
The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis. [PDF]
, 2020 Background: The cytokine growth differentiation factor-15 (GDF-15) has been associated with inflammatory and mitochondrial disease, warranting exploration of its expression in myositis patients.
De Bleecker, Jan +2 more
core +2 more sources
Differentiation-Induced Radioresistance in Muscle Cells [PDF]
Molecular and Cellular Biology, 2004 DNA damage induces cell cycle arrest and DNA repair or apoptosis in proliferating cells. Terminally differentiated cells are permanently withdrawn from the cell cycle and partly resistant to apoptosis. To investigate the effects of genotoxic agents in postmitotic cells, we compared DNA damage-activated responses in mouse and human proliferating ...
Latella Lucia +4 more
openaire +4 more sources
Interleukin-18 enhances vascular calcification and osteogenic differentiation of vascular smooth muscle cells through TRPM7 channel activation [PDF]
, 2017 Objective—Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors
Chen, Jie +7 more
core +1 more source
The Switch from NF-YAl to NF-YAs Isoform Impairs Myotubes Formation
Cells, 2020 NF-YA, the regulatory subunit of the trimeric transcription factor (TF) NF-Y, is regulated by alternative splicing (AS) generating two major isoforms, “long” (NF-YAl) and “short” (NF-YAs). Muscle cells express NF-YAl.
Debora Libetti +5 more
doaj +1 more source