Results 231 to 240 of about 3,838,500 (295)

A sterol reductase responsible for the unusual 8(14)-unsaturation in bacterial sterol production and degradation. [PDF]

J Bacteriol
Lee AK, Giner J-L, Welander PV.
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Transposon-based genome editing of industrial microorganisms: advances, challenges, and prospects. [PDF]

Synth Syst Biotechnol
Zhang Z, Huang Z, Wang Y, Li Z, Wen Z, Gu Y.   +5 more
europepmc   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Evolutionary insights into bilin biosynthesis: Functional characterization of pre-PcyA enzymes. [PDF]

Protein Sci
Frascogna F, Rockwell NC, Layer G, Frankenberg-Dinkel N.   +3 more
europepmc   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Promiscuity-Guided Enzyme Evolution via Substrate Multiplexed Screening. [PDF]

Angew Chem Int Ed Engl
Weilbaker HA, Campbell ME, Higgins PM, Buller AR.   +3 more
europepmc   +1 more source

Correction: P3 site-directed mutagenesis: An efficient method based on primer pairs with 3'-overhangs. [PDF]

J Biol Chem
Mousavi N, Zhou E, Razavi A, Ebrahimi E, Varela-Castillo P, Yang XJ.   +5 more
europepmc   +1 more source

An optimized CRISPR/Cas9-based genome editing platform enhances bacteriocin production in Lactiplantibacillus plantarum. [PDF]

J Biol Eng
Anand R, Lütticken R, De Laporte L, Herrmann A, Heine E.   +4 more
europepmc   +1 more source

Functional and mechanistic characterization of the phosphatidyl-<i>myo</i>-inositol mannosyltransferase PimA from <i>Mycobacterium tuberculosis</i>: implications for anti-tuberculosis drug development. [PDF]

Front Cell Infect Microbiol
Liu D, Deng H, Liu X, Yao W, Li N.
europepmc   +1 more source