Results 31 to 40 of about 300,317 (388)

Is Myelin a Mitochondrion? [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2012
It has been hypothesized that myelin acts like a mitochondrion, generating ATP across the membranes of its sheath. By calculating the proton motive force across the myelin membrane based on known values for the pH and membrane potential of the oligodendrocyte, we find that insufficient energy could be harvested from proton flow across the myelin ...
Julia J. Harris, David Attwell
openaire   +3 more sources

Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis

Journal of Neuroinflammation, 2023
The experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis was used in combination with a Cav1.2 conditional knock-out mouse (Cav1.2KO) to study the role of astrocytic voltage-gated Ca++ channels in autoimmune CNS inflammation and ...
G. E. Denaroso, Z. Smith, C. G. Angeliu, V. T. Cheli, C. Wang, P. M. Paez   +5 more
doaj   +1 more source

Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis

ASN Neuro, 2022
Although over 20 disease modifying therapies are approved to treat Multiple Sclerosis (MS), these do not increase remyelination of demyelinated axons or mitigate axon damage.
Jeffrey L. Dupree, Pablo M. Paez, Seema K. Tiwari-Woodruff, Travis T. Denton, Kenneth Hensley, Christina G. Angeliu, Anne I. Boullerne, Sergey Kalinin, Sophia Egge, Veronica T. Cheli, Giancarlo Denaroso, Kelley C. Atkinson, Micah Feri, Douglas L. Feinstein   +13 more
doaj   +1 more source

Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
doaj   +1 more source

Symptomatic care of late-onset Alexander disease presenting with area postrema-like syndrome with prednisolone; a case report

BMC Pediatrics, 2022
Background Alexander disease (AxD) is classified into AxD type I (infantile) and AxD type II (juvenile and adult form). We aimed to determine the potential genetic cause(s) contributing to the AxD type II manifestations in a 9-year-old male who presented
Safoura Zardadi, Ehsan Razmara, Maryam Rasoulinezhad, Meisam Babaei, Mohammad Reza Ashrafi, Neda Pak, Masoud Garshasbi, Ali Reza Tavasoli   +7 more
doaj   +1 more source

The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases

Brain Sciences, 2022
Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis, Konstantinos Kelaidonis, Harry Ridgway, Vasso Apostolopoulos, John M. Matsoukas   +4 more
doaj   +1 more source

Myelination and mTOR [PDF]

Glia, 2017
AbstractMyelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination.
Gianluca Figlia, Daniel Gerber, Ueli Suter   +2 more
openaire   +4 more sources

Myelin: A gatekeeper of activity-dependent circuit plasticity?

Science, 2021
Description Insulation for circuit regulation Lipid-rich myelin, which wraps around and insulates neuronal axons, improves the speed and efficiency of signal propagation.
Giulia Bonetto, D. Belin, R. Káradóttir   +2 more
semanticscholar   +1 more source

Myelination at a glance [PDF]

Journal of Cell Science, 2014
ABSTRACTThe myelin sheath is a plasma membrane extension that is laid down in regularly spaced segments along axons of the nervous system. This process involves extensive changes in oligodendrocyte cell shape and membrane architecture. In this Cell Science at a Glance article and accompanying poster, we provide a model of how myelin of the central ...
Snaidero, Nicolas, Simons, Mikael
openaire   +4 more sources

Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits

Nature Communications, 2020
Myelination optimizes conduction speed of excitatory neurons. However, whether myelination of interneurons (INs) refines cortical networks is unclear.
Najate Benamer, Marie Vidal, Maddalena Balia, María Cecilia Angulo   +3 more
doaj   +1 more source