Bilateral horizontal gaze palsy in an 8‐year‐old girl: A rare case with NDUFS4 gene mutation
Clinical Case Reports, 2021 We report a patient with complex clinical presentation including multiple neurological symptoms and eye involvement. Upon genetic investigation, the patient was found to carry a novel homozygous mutation in the NDUFS4 gene, thus adding to the ...
Mohammad Vafaee‐Shahi +6 more
doaj +1 more source
Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism
Cells, 2020 Myelin is critical for the proper function of the nervous system and one of the most complex cell–cell interactions of the body. Myelination allows for the rapid conduction of action potentials along axonal fibers and provides physical and trophic ...
Y. Poitelon +2 more
semanticscholar +1 more source
Polarization and Myelination in Myelinating Glia [PDF]
ISRN Neurology, 2012 Myelinating glia, oligodendrocytes in central nervous system and Schwann cells in peripheral nervous system, form myelin sheath, a multilayered membrane system around axons enabling salutatory nerve impulse conduction and maintaining axonal integrity.
openaire +2 more sources
Learning Myelin Content in Multiple Sclerosis from Multimodal MRI through Adversarial Training [PDF]
, 2018 Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). A reliable measure of the tissue myelin content is therefore essential for the understanding of the physiopathology of MS, tracking progression and assessing ...
Ayache, Nicholas +6 more
core +3 more sources
Oligodendrocytes in Development, Myelin Generation and Beyond
Cells, 2019 Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the CNS and represent a pool of migratory and proliferative adult progenitor ...
S. Kuhn +3 more
semanticscholar +1 more source
EMBO Molecular Medicine, 2019 Current treatments in multiple sclerosis (MS) are modulating the inflammatory component of the disease, but no drugs are currently available to repair lesions.
Fabien Binamé +12 more
doaj +1 more source
Myelin in the Central Nervous System: Structure, Function, and Pathology.
Physiological Reviews, 2019 Oligodendrocytes generate multiple layers of myelin membrane around axons of the central nervous system to enable fast and efficient nerve conduction.
C. Stadelmann +3 more
semanticscholar +1 more source
Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system. [PDF]
PLoS ONE, 2010 Inflammatory response following central nervous system (CNS) injury contributes to progressive neuropathology and reduction in functional recovery. Axons are sensitive to mechanical injury and toxic inflammatory mediators, which may lead to demyelination.
Xin Sun +11 more
doaj +1 more source
Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]
, 2019 The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F. +4 more
core +1 more source
White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes
Acta Neuropathologica Communications, 2018 Alzheimer’s disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary tangles.
S. E. Nasrabady +3 more
semanticscholar +1 more source