Results 21 to 30 of about 6,136 (180)
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
core +2 more sources
eLife, 2018 Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function ...
Elizabeth A Gould +9 more
doaj +1 more source
Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis [PDF]
, 2013 PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Amor, S +13 more
core +5 more sources
NeuroImage, 2020 Quantitative evaluation of brain myelination has drawn considerable attention. Conventional diffusion-based magnetic resonance imaging models, including diffusion tensor imaging and diffusion kurtosis imaging (DKI),11 AD: Axial diffusivity; AK: Axial ...
Zihan Zhou +9 more
doaj +1 more source
The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix. [PDF]
PLoS ONE, 2014 In the central nervous system, lipid-protein interactions are pivotal for myelin maintenance, as these interactions regulate protein transport to the myelin membrane as well as the molecular organization within the sheath. To improve our understanding of
Hande Ozgen +7 more
doaj +1 more source
Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]
, 2018 There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa +4 more
core +3 more sources
The Multiple Roles of Myelin Protein Genes During the Development of the Oligodendrocyte
ASN Neuro, 2009 It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2′, 3′-cyclic nucleotide 3′-
Daniel Fulton +2 more
doaj +1 more source
ASN Neuro, 2021 A founder mutation in human VPS11 ( Vacuolar Protein Sorting 11 ) was recently linked to a genetic leukoencephalopathy in Ashkenazi Jews that presents with the classical features of white matter disorders of the central nervous system (CNS).
Robert P. Skoff +4 more
doaj +1 more source
In Silico Structural Analysis Predicting the Pathogenicity of PLP1 Mutations in Multiple Sclerosis
Brain Sciences, 2022 The X chromosome gene PLP1 encodes myelin proteolipid protein (PLP), the most prevalent protein in the myelin sheath surrounding the central nervous system.
Antigoni Avramouli +3 more
doaj +1 more source
NeuroImage, 2020 Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image processing pipeline for quantitative susceptibility mapping (QSM) and R2* mapping of fixed post-mortem ...
Chaoyue Wang +11 more
doaj +1 more source