Results 31 to 40 of about 6,136 (180)

Myelin‐specific T cells in animals with Japanese macaque encephalomyelitis

Annals of Clinical and Translational Neurology, 2021
Objective To determine whether animals with Japanese macaque encephalomyelitis (JME), a spontaneous demyelinating disease similar to multiple sclerosis (MS), harbor myelin‐specific T cells in their central nervous system (CNS) and periphery.
Aparna N. Govindan, Kristin S. Fitzpatrick, Minsha Manoharan, Ian Tagge, Steven G. Kohama, Betsy Ferguson, Samuel M. Peterson, Grayson S. Wong, William D. Rooney, Byung Park, Michael K. Axthelm, Dennis N. Bourdette, Larry S. Sherman, Scott W. Wong   +13 more
doaj   +1 more source

Critical role for prokineticin 2 in CNS autoimmunity [PDF]

, 2015
Objective: To investigate the potential role of prokineticin 2 (PK2), a bioactive peptide involved in multiple biological functions including immune modulation, in CNS autoimmune demyelinating disease.
ABOU HAMDAN M, BALBONI, GIANFRANCO, CONGIU, CENZO, COSTANZA M, DI DARIO M, FARINA C, FONTANA E, LATTANZI R, MARTINELLI V, MUSIO S, NEGRI L, ONNIS, VALENTINA, PEDOTTI R., POLIANI PL, RADAELLI M, SALVADORI S, STEINMAN L   +16 more
core   +1 more source

Axon-glia interaction and membrane traffic in myelin formation

Frontiers in Cellular Neuroscience, 2014
In vertebrate nervous systems myelination of neuronal axons has evolved to increase conduction velocity of electrical impulses with minimal space and energy requirements.
Robin eWhite, Eva-Maria eKrämer-Albers
doaj   +1 more source

Mature and Myelinating Oligodendrocytes Are Specifically Vulnerable to Mild Fluid Percussion Injury in Mice

Neurotrauma Reports, 2023
Myelin loss and oligodendrocyte death are well documented in patients with traumatic brain injury (TBI), as well as in experimental animal models after moderate-to-severe TBI.
Alexandra A. Adams, Teresa L. Wood, Haesun A. Kim   +2 more
doaj   +1 more source

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy [PDF]

, 2017
Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of ...
Asadollahi, Ebrahim, Baes, Myriam, Blanz, Judith, Brügger, Britta, de Hoz, Livia, Kassmann, Celia Michèle, Kleinecke, Sandra, Kungl, Theresa, Lüchtenborg, Christian, McGonigal, Rhona, Möbius, Wiebke, Naseri, Kobra, Nave, Klaus-Armin, Quintes, Susanne, Richert, Sarah, Sachsenheimer, Timo, Sereda, Michael W., Willison, Hugh   +17 more
core   +3 more sources

Assembly of CNS Myelin in the Absence of Proteolipid Protein [PDF]

Neuron, 1997
Two proteolipid proteins, PLP and DM20, are the major membrane components of central nervous system (CNS) myelin. Mutations of the X-linked PLP/DM20 gene cause dysmyelination in mouse and man and result in significant mortality. Here we show that mutant mice that lack expression of a targeted PLP gene fail to exhibit the known dysmyelinated phenotype ...
Klugmann, Matthias, Schwab, Markus H., Pühlhofer, Anja, Schneider, Armin, Zimmermann, Frank, Griffiths, Ian R., Nave, Klaus-Armin   +6 more
openaire   +2 more sources

Increased Gene Expression Leads to Massive Microglial Cell Activation and Inflammation Throughout the Brain

ASN Neuro, 2010
PMD (Pelizaeus-Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan.
Carrie L Tatar, Sunita Appikatla, Denise A Bessert, Ajaib S Paintlia, Inderjit Singh, Robert P Skoff   +5 more
doaj   +1 more source

Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]

, 2007
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland, Esparza, Fitzgerald, Harbige, Harbige, Jones, Karpus, Laurence S. Harbige, Mohammad K. Sharief, Mokhtarian, Ovadia, Santambrogio, Selmaj, Serafina, Thompson, Thompson, Vartanian   +16 more
core   +2 more sources

Tertiary lymphoid organs in central nervous system autoimmunity [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
core   +1 more source

Generation of the human induced pluripotent stem cell line (ZJUi005-A) from a patient with Pelizaeus-Merzbacher disease (PMD) carrying a novel hemizygous mutation in PLP1 gene

Stem Cell Research, 2020
Pelizaeus-Merzbacher disease (PMD) is a rare X-linked leukodystrophy caused by mutations in the proteolipid protein 1 gene (PLP1) which is specifically expressed on the myelin sheath of oligodendrocytes.
Bei Liu, Lang Chen, Jian Sun, Li Zhang, Min Chen, Yeqing Qian, Yanlin Wang, Kai Yan, Linxiao Hou, Yingzhi Huang, Dan Zhang, Yuming Xu, Jialing Yu, Jin Zhang, Minyue Dong   +14 more
doaj   +1 more source