Proteome Profile of Myelin in the Zebrafish Brain [PDF]
Frontiers in Cell and Developmental Biology, 2021 The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems +7 more
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Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice [PDF]
eLife, 2022 Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki‐Ilya Gargareta +12 more
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The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases [PDF]
Brain Sciences, 2022 Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis +4 more
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Proteome profile of peripheral myelin in healthy mice and in a neuropathy model [PDF]
eLife, 2020 Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B. Siems +13 more
doaj +7 more sources
The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay [PDF]
Frontiers in Cellular Neuroscience, 2020 Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn +8 more
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Proteomic analysis of peripheral nerve myelin during murine aging [PDF]
Frontiers in Cellular Neuroscience, 2023 Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Dario Lucas Helbing +13 more
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Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?
Metabolites, 2021 Myelin is a lipid-rich membrane that wraps around axons and facilitates rapid action potential propagation. In the brain, myelin is synthesized and maintained by oligodendrocytes.
Niklas Meyer, Johanne Egge Rinholm
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Molecular Neurodegeneration, 2023 Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention ...
Jun Yup Lee +6 more
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Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. [PDF]
PLoS ONE, 2009 The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS).
Ralf A Linker +9 more
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Study on Tissue Homogenization Buffer Composition for Brain Mass Spectrometry-Based Proteomics
Biomedicines, 2022 Mass spectrometry-based proteomics aims to study the proteome both qualitatively and quantitatively. A key step in proteomic analysis is sample preparation, which is crucial for reliable results.
Adam Aleksander Karpiński +7 more
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