Results 1 to 10 of about 13,038 (207)

The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases. [PDF]

Brain Sci, 2022
Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Chasapis CT, Kelaidonis K, Ridgway H, Apostolopoulos V, Matsoukas JM.   +4 more
europepmc   +8 more sources

The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay. [PDF]

Front Cell Neurosci, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Jahn O, Siems SB, Kusch K, Hesse D, Jung RB, Liepold T, Uecker M, Sun T, Werner HB.   +8 more
europepmc   +9 more sources

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice. [PDF]

Elife, 2022
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Gargareta VI, Reuschenbach J, Siems SB, Sun T, Piepkorn L, Mangana C, Späte E, Goebbels S, Huitinga I, Möbius W, Nave KA, Jahn O, Werner HB.   +12 more
europepmc   +11 more sources

Proteome Profile of Myelin in the Zebrafish Brain [PDF]

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Tim Czopka, Hauke Werner   +7 more
doaj   +8 more sources

Proteome profile of peripheral myelin in healthy mice and in a neuropathy model [PDF]

eLife, 2020
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B. Siems, Olaf Jahn, Maria A. Eichel‐Vogel, Nirmal Kannaiyan, Lai Man Natalie Wu, Diane L. Sherman, Kathrin Kusch, Dörte Hesse, Ramona B. Jung, Robert Fledrich, Michael W. Sereda, Moritz J. Rossner, Peter Brophy, Hauke Werner   +13 more
doaj   +8 more sources

CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment. [PDF]

Alzheimers Dement (N Y)
INTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline ...
Hajós M, Pandey K, Singer AC, Duong D, Bitarafan S, Shpokayte M, Malchano Z, Kern R, Lah JJ, Levey AI, Seyfried NT.   +10 more
europepmc   +4 more sources

Human myelin proteome and comparative analysis with mouse myelin. [PDF]

Proc Natl Acad Sci U S A, 2009
Myelin, formed by oligodendrocytes (OLs) in the CNS, is critical for axonal functions, and its damage leads to debilitating neurological disorders such as multiple sclerosis. Understanding the molecular mechanisms of myelination and the pathogenesis of human myelin disease has been limited partly by the relative lack of identification and functional ...
Ishii A, Dutta R, Wark GM, Hwang SI, Han DK, Trapp BD, Pfeiffer SE, Bansal R.   +7 more
europepmc   +5 more sources

Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome. [PDF]

Glia
AbstractThe molecules that constitute myelin are critical for the integrity of axon/myelin‐units and thus speed and precision of impulse propagation. In the CNS, the protein composition of oligodendrocyte‐derived myelin has evolutionarily diverged and differs from that in the PNS.
Siems SB, Gargareta VI, Schadt LC, Daguano Gastaldi V, Jung RB, Piepkorn L, Casaccia P, Sun T, Jahn O, Werner HB.   +9 more
europepmc   +7 more sources

Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions. [PDF]

Front Mol Neurosci
BackgroundMultiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by increased inflammation and immune responses, oxidative injury, mitochondrial dysfunction, and iron dyshomeostasis leading to demyelination and ...
Wilkins JM, Mangalaparthi KK, Netzel BC, Sherman WA, Guo Y, Kalinowska-Lyszczarz A, Pandey A, Lucchinetti CF.   +7 more
europepmc   +2 more sources

AAV-mediated delivery of a proliferation inducing ligand (APRIL) to cortical neurons limits inflammation and demyelination in the corpus callosum of the cuprizone mouse model. [PDF]

J Neuroinflammation
Background A Proliferation-Inducing Ligand (APRIL) is a tumour necrosis factor superfamily member with multiple effector roles in the peripheral and central nervous system (CNS).
Ricciardi L, Di Marco F, Decrop M, Di Stefano J, Kakunuri T, van Rijswijk J, Vidas-Guscic N, El Ouaamari Y, Bufi AA, Van Spilbeeck I, Van Audekerke J, Faghel C, Bartholomeus E, Lion E, Cools N, Van Laere S, Cicalini I, De Laurenzi V, FitzGerald U, Pieragostino D, Huard B, Del Boccio P, Ponsaerts P, Verhoye M.   +23 more
europepmc   +2 more sources