Results 11 to 20 of about 12,983 (206)

Proteome profile of peripheral myelin in healthy mice and in a neuropathy model [PDF]

eLife, 2020
Proteome and transcriptome analyses aim at comprehending the molecular profiles of the brain, its cell-types and subcellular compartments including myelin.
Sophie B Siems, Olaf Jahn, Maria A Eichel, Nirmal Kannaiyan, Lai Man N Wu, Diane L Sherman, Kathrin Kusch, Dörte Hesse, Ramona B Jung, Robert Fledrich, Michael W Sereda, Moritz J Rossner, Peter J Brophy, Hauke B Werner   +13 more
doaj   +6 more sources

CDC42-Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity. [PDF]

Glia
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Hümmert S, de Faria JP, Jahn O, Bilgin E, Łukasik N, Rao C, Mitkovski M, Benseler F, Brose N, Siems SB, Goebbels S, Möbius W, Ewers H, Relvas JB, Werner HB.   +14 more
europepmc   +2 more sources

Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome. [PDF]

Glia
AbstractThe molecules that constitute myelin are critical for the integrity of axon/myelin‐units and thus speed and precision of impulse propagation. In the CNS, the protein composition of oligodendrocyte‐derived myelin has evolutionarily diverged and differs from that in the PNS.
Siems SB, Gargareta VI, Schadt LC, Daguano Gastaldi V, Jung RB, Piepkorn L, Casaccia P, Sun T, Jahn O, Werner HB.   +9 more
europepmc   +5 more sources

Human myelin proteome and comparative analysis with mouse myelin. [PDF]

Proc Natl Acad Sci U S A, 2009
Myelin, formed by oligodendrocytes (OLs) in the CNS, is critical for axonal functions, and its damage leads to debilitating neurological disorders such as multiple sclerosis. Understanding the molecular mechanisms of myelination and the pathogenesis of human myelin disease has been limited partly by the relative lack of identification and functional ...
Ishii A, Dutta R, Wark GM, Hwang SI, Han DK, Trapp BD, Pfeiffer SE, Bansal R.   +7 more
europepmc   +4 more sources

Myelin Proteomics: Molecular Anatomy of an Insulating Sheath [PDF]

Molecular Neurobiology, 2009
Fast-transmitting vertebrate axons are electrically insulated with multiple layers of nonconductive plasma membrane of glial cell origin, termed myelin. The myelin membrane is dominated by lipids, and its protein composition has historically been viewed to be of very low complexity.
Jahn, O., Tenzer, S., Werner, H.
openaire   +4 more sources

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Molecular Neurodegeneration, 2023
Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention ...
Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T. Sutherland, Mark Larance, Anthony S Don   +6 more
doaj   +1 more source

Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. [PDF]

PLoS ONE, 2009
The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS).
Ralf A Linker, Peter Brechlin, Sarah Jesse, Petra Steinacker, D H Lee, Abdul R Asif, Olaf Jahn, Hayrettin Tumani, Ralf Gold, Markus Otto   +9 more
doaj   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

Study on Tissue Homogenization Buffer Composition for Brain Mass Spectrometry-Based Proteomics

Biomedicines, 2022
Mass spectrometry-based proteomics aims to study the proteome both qualitatively and quantitatively. A key step in proteomic analysis is sample preparation, which is crucial for reliable results.
Adam Aleksander Karpiński, Julio Cesar Torres Elguera, Anne Sanner, Witold Konopka, Leszek Kaczmarek, Dominic Winter, Anna Konopka, Ewa Bulska   +7 more
doaj   +1 more source

Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics

Cells, 2023
Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS). Its intracellular interaction network is still partially deconvoluted due to the unfolded structure, abnormally basic charge, and specific cellular localization.
Evgeniya V. Smirnova, Tatiana V. Rakitina, Rustam H. Ziganshin, George A. Saratov, Georgij P. Arapidi, Alexey A. Belogurov, Anna A. Kudriaeva   +6 more
openaire   +3 more sources