Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5 [PDF]
eLife, 2022 Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown.
Tobias J Buscham +16 more
doaj +3 more sources
Absence of miRNA-146a Differentially Alters Microglia Function and Proteome [PDF]
Frontiers in Immunology, 2020 Background: MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival.Methods: By sorting CNS resident cells, microglia were the main cellular source of miR-146a.
Nellie A. Martin +20 more
doaj +4 more sources
Identification of protein networks involved in the disease course of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. [PDF]
PLoS ONE, 2012 A more detailed insight into disease mechanisms of multiple sclerosis (MS) is crucial for the development of new and more effective therapies. MS is a chronic inflammatory autoimmune disease of the central nervous system.
Annelies Vanheel +11 more
doaj +8 more sources
The peritumoral brain zone in glioblastoma: where we are and where we are going
Journal of Neuroscience Research, Volume 101, Issue 2, Page 199-216, February 2023., 2023 Abstract Glioblastoma (GBM) is the most aggressive and invasive primary brain tumor. Current therapies are not curative, and patients' outcomes remain poor with an overall survival of 20.9 months after surgery. The typical growing pattern of GBM develops by infiltrating the surrounding apparent normal brain tissue within which the recurrence is ...
Martina Giambra +8 more
wiley +1 more source
Biology, 2022 Proteomic analysis revealed the preservation of many proteins in the Heslington brain (which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 from a pit in Heslington, Yorkshire, England).
Aaron S. Mohammed, Vladimir N. Uversky
doaj +1 more source
Neural Plasticity, 2023 Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa +8 more
doaj +1 more source
New species can broaden myelin research: suitability of little skate, Leucoraja erinacea [PDF]
, 2021 © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Moebius, W., Huemmert, S., Ruhwedel, T., Kuzirian, A., & Gould, R.
Gould, Robert M. +4 more
core +1 more source
A space-fractional cable equation for the propagation of action potentials in myelinated neurons [PDF]
Emerging Science Journal, Vol. 4, No. 3: 148-164, 2020, 2020 Myelinated neurons are characterized by the presence of myelin, a multilaminated wrapping around the axons formed by specialized neuroglial cells. Myelin acts as an electrical insulator and therefore, in myelinated neurons, the action potentials do not propagate within the axons but happen only at the nodes of Ranvier which are gaps in the axonal ...
arxiv +1 more source
Proteomics of Multiple Sclerosis : inherent issues in defining the pathoetiology and identifying (early) biomarkers [PDF]
, 2021 Multiple Sclerosis (MS) is a demyelinating disease of the human central nervous system having an unconfirmed pathoetiology. Although animal models are used to mimic the pathology and clinical symptoms, no single model successfully replicates the full ...
Almuslehi, Mohammed S. (S32978) +4 more
core +1 more source
Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis. [PDF]
PLoS ONE, 2016 BACKGROUND:Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1)-specific CD4+ T cells that cross-recognize MS ...
Monika Tschochner +11 more
doaj +1 more source