Results 21 to 30 of about 13,038 (207)

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Molecular Neurodegeneration, 2023
Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention ...
Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T. Sutherland, Mark Larance, Anthony S Don   +6 more
doaj   +1 more source

Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics investigation of neurodevelopmental migratory pathways [PDF]

, 2020
Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms underlying GCD remain to be elucidated, but one hypothesis proposes aberrant reactivation of
Al-Kaaby, B., Al-Kaaby, B., Dzurova, N., Dzurova, N., Liu, J., Liu, J., Millks, K., Millks, K., Sisodiya, S.M., Sisodiya, S.M., Thom, M., Thom, M.   +11 more
core   +1 more source

Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. [PDF]

PLoS ONE, 2009
The identification of new biomarkers is of high interest for the prediction of the disease course and also for the identification of pathomechanisms in multiple sclerosis (MS).
Ralf A Linker, Peter Brechlin, Sarah Jesse, Petra Steinacker, D H Lee, Abdul R Asif, Olaf Jahn, Hayrettin Tumani, Ralf Gold, Markus Otto   +9 more
doaj   +1 more source

Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke. [PDF]

Funct Integr Genomics
Ischemic stroke (IS), a leading cause of global disability and mortality, is characterized by white matter damage and demyelination. Despite advances, the molecular mechanisms driving post-IS myelin pathology remain poorly understood, limiting therapeutic development. This study investigates key myelin-related genes (MRGs) and their regulatory networks
Qian Q, Lyu H, Wang W, Wang Q, Li D, Liu X, He Y, Shen M.   +7 more
europepmc   +3 more sources

Study on Tissue Homogenization Buffer Composition for Brain Mass Spectrometry-Based Proteomics

Biomedicines, 2022
Mass spectrometry-based proteomics aims to study the proteome both qualitatively and quantitatively. A key step in proteomic analysis is sample preparation, which is crucial for reliable results.
Adam Aleksander Karpiński, Julio Cesar Torres Elguera, Anne Sanner, Witold Konopka, Leszek Kaczmarek, Dominic Winter, Anna Konopka, Ewa Bulska   +7 more
doaj   +1 more source

Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics

Cells, 2023
Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS). Its intracellular interaction network is still partially deconvoluted due to the unfolded structure, abnormally basic charge, and specific cellular localization.
Evgeniya V. Smirnova, Tatiana V. Rakitina, Rustam H. Ziganshin, George A. Saratov, Georgij P. Arapidi, Alexey A. Belogurov, Anna A. Kudriaeva   +6 more
openaire   +3 more sources

The proteome of remyelination is different from that of developmental myelination [PDF]

, 2021
AbstractLoss of myelin underlies the pathology of several neurological disorders of diverse etiology. CNS remyelination by adult oligodendrocyte progenitor cells (OPCs) can occur but it differs from developmental myelination carried out by neonatal OPCs. We asked whether the myelin proteome of remyelinated regions is changed.
Joana Paes de Faria, Maria M. Azevedo, Damaris Bausch-Fluck, Ana Seixas, Helena S. Domingues, Maria A. Monteiro, Patrick G.A. Pedrioli, Eduarda Lopes, Rui Fernandes, Chao Zhao, Robin J. M. Franklin, Bernd Wollscheid, Joao B. Relvas, Laura Montani   +13 more
openaire   +1 more source

Intrinsic Disorder as a Natural Preservative: High Levels of Intrinsic Disorder in Proteins Found in the 2600-Year-Old Human Brain

Biology, 2022
Proteomic analysis revealed the preservation of many proteins in the Heslington brain (which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 from a pit in Heslington, Yorkshire, England).
Aaron S. Mohammed, Vladimir N. Uversky
doaj   +1 more source

Proteomic mapping provides powerful insights into functional myelin biology [PDF]

Proceedings of the National Academy of Sciences, 2004
Myelin is a dynamic, functionally active membrane necessary for rapid action potential conduction, axon survival, and cytoarchitecture. The number of debilitating neurological disorders that occur when myelin is disrupted emphasizes its importance. Using high-resolution 2D gel electrophoresis, mass spectrometry, and immunoblotting, we have developed an
Christopher M, Taylor, Cecilia B, Marta, Robert J, Claycomb, David K, Han, Matthew N, Rasband, Timothy, Coetzee, Steven E, Pfeiffer   +6 more
openaire   +2 more sources

Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

Neural Plasticity, 2023
Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa, Naosuke Kamei, Yohei Sanada, Toshio Nakamae, Takahiro Harada, Kazunori Imaizumi, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi   +8 more
doaj   +1 more source