Fully denaturing two-dimensional electrophoresis of membrane proteins: a critical update [PDF]
, 2008 The quality and ease of proteomics analysis depends on the performance of the analytical tools used, and thus of the performances of the protein separation tools used to deconvolute complex protein samples.
Adessi +95 more
core +4 more sources
eLife, 2022 The age and sex of studied animals profoundly impact experimental outcomes in biomedical research. However, most preclinical studies in mice use a wide-spanning age range from 4 to 20 weeks and do not assess male and female mice in parallel.
Feng Xian +3 more
doaj +1 more source
Acta Neuropathologica Communications, 2018 Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear.
Qi Zhang +5 more
doaj +1 more source
Nanoscale correlated disorder in out-of-equilibrium myelin ultrastructure [PDF]
ACS Nano 12(1), 729-739 (2018), 2017 Ultrastructural fluctuations at nanoscale are fundamental to assess properties and functionalities of advanced out-of-equilibrium materials. We have taken myelin as a model of supramolecular assembly in out-of-equilibrium living matter. Myelin sheath is a simple stable multi-lamellar structure of high relevance and impact in biomedicine. Although it is
arxiv +1 more source
Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma. [PDF]
PLoS ONE, 2014 Lacunar infarction (LACI) is a subtype of acute ischemic stroke affecting around 25% of all ischemic stroke cases. Despite having an excellent recovery during acute phase, certain LACI patients have poor mid- to long-term prognosis due to the recurrence ...
Arnab Datta +2 more
doaj +1 more source
Quantitative profiling of brain lipid raft proteome in a mouse model of fragile X syndrome. [PDF]
PLoS ONE, 2015 Fragile X Syndrome, a leading cause of inherited intellectual disability and autism, arises from transcriptional silencing of the FMR1 gene encoding an RNA-binding protein, Fragile X Mental Retardation Protein (FMRP).
Magdalena Kalinowska +2 more
doaj +1 more source
Thrombin regulates the ability of Schwann cells to support neuritogenesis and to maintain the integrity of the nodes of Ranvier [PDF]
, 2020 Schwann cells (SC) are characterized by a remarkable plasticity that enables them to promptly respond to nerve injury promoting axonal regeneration. In peripheral nerves after damage SC convert to a repair-promoting phenotype activating a sequence of ...
Ciraci, Viviana +9 more
core +2 more sources
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia [PDF]
, 2021 Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1 loss
Bremova-Ertl, Tatiana +15 more
core +1 more source
gACSON software for automated segmentation and morphology analyses of myelinated axons in 3D electron microscopy [PDF]
arXiv, 2021 Background and Objective: Advances in electron microscopy (EM) now allow three-dimensional (3D) imaging of hundreds of micrometers of tissue with nanometer-scale resolution, providing new opportunities to study the ultrastructure of the brain. In this work, we introduce a freely available Matlab-based gACSON software for visualization, segmentation ...
arxiv
What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]
, 2018 Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
core +1 more source