Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]
, 2018 Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika +3 more
core +1 more source
Protein expression profiling in rat hippocampus after focal cerebral ischemia injury [PDF]
Journal of Integrative Neuroscience, 2018 The aim in this study was to explore protein expression profiles in the rat hippocampus after induction of focal ischemia injury. Forty male Sprague Dawley rats were randomly divided into four equal groups after ischemia injury surgery: Control, Day 3 ...
Lichan He, Rui He, Ruihua Liang, Yi Li, Xiaoqiang Li, Chuqiao Li, Suping Zhang
doaj +1 more source
Power and limitations of electrophoretic separations in proteomics strategies [PDF]
, 2009 Proteomics can be defined as the large-scale analysis of proteins. Due to the complexity of biological systems, it is required to concatenate various separation techniques prior to mass spectrometry.
Aebersold +225 more
core +4 more sources
Comprehensive Phenotyping in Multiple Sclerosis: Discovery Based Proteomics and the Current Understanding of Putative Biomarkers [PDF]
, 2014 Currently, there is no single test for multiple sclerosis (MS). Diagnosis is confirmed through clinical evaluation, abnormalities revealed by magnetic resonance imaging (MRI), and analysis of cerebrospinal fluid (CSF) chemistry.
Becker, Christopher H. +4 more
core +1 more source
Proteomic analysis of nuclear factors binding to an intronic enhancer in the myelin proteolipid protein gene [PDF]
Journal of Neurochemistry, 2008 AbstractThe myelin proteolipid protein gene (Plp1) encodes the most abundant protein found in CNS myelin, accounting for nearly one‐half of the total protein. Its expression in oligodendrocytes is developmentally regulated – peaking during the active myelination period of CNS development. Previously, we have identified a novel enhancer (designated ASE)
Anna, Dobretsova +4 more
openaire +2 more sources
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]
, 2017 Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan +13 more
core +3 more sources
Thrombin regulates the ability of Schwann cells to support neuritogenesis and to maintain the integrity of the nodes of Ranvier [PDF]
, 2020 Schwann cells (SC) are characterized by a remarkable plasticity that enables them to promptly respond to nerve injury promoting axonal regeneration. In peripheral nerves after damage SC convert to a repair-promoting phenotype activating a sequence of ...
Ciraci, Viviana +9 more
core +2 more sources
Acta Neuropathologica Communications, 2018 Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear.
Qi Zhang +5 more
doaj +1 more source
Absence of miRNA-146a Differentially Alters Microglia Function and Proteome
Frontiers in Immunology, 2020 Background: MiR-146a is an important regulator of innate inflammatory responses and is also implicated in cell death and survival.Methods: By sorting CNS resident cells, microglia were the main cellular source of miR-146a.
Nellie A. Martin +20 more
doaj +1 more source
Fully denaturing two-dimensional electrophoresis of membrane proteins: a critical update [PDF]
, 2008 The quality and ease of proteomics analysis depends on the performance of the analytical tools used, and thus of the performances of the protein separation tools used to deconvolute complex protein samples.
Adessi +95 more
core +5 more sources