Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
Journal of Neuroinflammation, 2012 Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing +9 more
doaj +1 more source
Protein Kinase C Activation Drives a Differentiation Program in an Oligodendroglial Precursor Model through the Modulation of Specific Biological Networks [PDF]
, 2021 Protein kinase C (PKC) activation induces cellular reprogramming and differentiation in various cell models. Although many effectors of PKC physiological actions have been elucidated, the molecular mechanisms regulating oligodendrocyte differentiation ...
Cardon T +8 more
core +1 more source
In silico Proteome Cleavage Reveals Iterative Digestion Strategy for High Sequence Coverage [PDF]
ISRN Computational Biology 2014, 2014 In the post-genome era, biologists have sought to measure the complete complement of proteins, termed proteomics. Currently, the most effective method to measure the proteome is with shotgun, or bottom-up, proteomics, in which the proteome is digested into peptides that are identified followed by protein inference.
arxiv +1 more source
MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles [PDF]
, 2020 Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized.
Alberro, Ainhoa +17 more
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On the stability and growth of single myelin figures [PDF]
Phys. Rev. Lett. 96, 138301 (2006), 2005 Myelin figures are long thin cylindrical structures that typically grow as a dense tangle when water is added to the concentrated lamellar phase of certain surfactants. We show that, starting from a well-ordered initial state, single myelin figures can be produced in isolation thus allowing a detailed study of their growth and stability.
arxiv +1 more source
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
eLife, 2019 The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange factor eIF2B ...
Yao Liang Wong +21 more
doaj +1 more source
Glia, EarlyView.Zdhhc9 ablation grossly changes gene expression and myelin protein levels in CNS WM. Zdhhc9 is important for the establishment of mature oligodendrocyte subtypes. Zdhhc9 is important for axon myelination and the maintenance of myelin integrity. ABSTRACT Two percent of patients with X‐linked intellectual disability (XLID) exhibit loss‐of‐function ...
Rocio B. White +9 more
wiley +1 more source
Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum). [PDF]
PLoS ONE, 2014 This study describes a combined transcriptome and proteome analysis of Monodelphis domestica response to spinal cord injury at two different postnatal ages.
Norman R Saunders +13 more
doaj +1 more source
Frontiers in Immunology, 2022 Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system (CNS). Although inflammatory responses are efficiently treated, therapies for progression are scarce and suboptimal, and biomarkers to predict
Maria L. Elkjaer +7 more
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Differential neuroproteomic and systems biology analysis of spinal cord injury [PDF]
, 2016 Acute spinal cord injury (SCI) is a devastating condition with many consequences and no known effective treatment. Although it is quite easy to diagnose traumatic SCI, the assessment of injury severity and projection of disease progression or recovery ...
Bramlett, Helen M +8 more
core +2 more sources