Results 71 to 80 of about 7,776 (138)

Tgm2‐Catalyzed Covalent Cross‐Linking of IκBα Drives NF‐κB Nuclear Translocation to Promote SASP in Senescent Microglia

Aging Cell, EarlyView.
Tgm2 is highly expressed in senescent microglia. The Tgm2‐NF‐κB‐SASP loop facilitates senescence in microglia. Tgm2‐catalyzed covalent crosslinking of IκBα at K22 and Q248 in the cytoplasm of senescent microglia leads to a reduction in IκBα levels and NF‐κB nuclear translocation.
Zhiqiang Li, Tianxiang Wang, Sijing Du, Zelong Miao, Yujiao Zhao, Yuxiang Tang, Xianbin Meng, Shangcheng Yu, Dongyuan Zhang, Hao Jiang, Kunlin Du, Wei Wei, Haiteng Deng   +12 more
wiley   +1 more source

Changes of statistical structural fluctuations unveils an early compacted degraded stage of PNS myelin [PDF]

Scientific Reports 4, 5430 (2014), 2013
Degradation of the myelin sheath is a common pathology underlying demyelinating neurological diseases from Multiple Sclerosis to Leukodistrophies. Although large malformations of myelin ultrastructure in the advanced stages of Wallerian degradation is known, its subtle structural variations at early stages of demyelination remains poorly characterized.
arxiv   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Alzheimer disease pathology and the cerebrospinal fluid proteome

Alzheimer’s Research & Therapy, 2018
Background Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have ...
Loïc Dayon, Antonio Núñez Galindo, Jérôme Wojcik, Ornella Cominetti, John Corthésy, Aikaterini Oikonomidi, Hugues Henry, Martin Kussmann, Eugenia Migliavacca, India Severin, Gene L. Bowman, Julius Popp   +11 more
doaj   +1 more source

Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models

Frontiers in Cell and Developmental Biology, 2020
Disease modeling requires appropriate cellular models that best mimic the underlying pathophysiology. Human origin and an adequate expression of the disease protein are pre-requisites that support information from a model to be meaningful.
Stefan Hauser, Stefan Hauser, Stefanie Schuster, Stefanie Schuster, Stefanie Schuster, Elena Heuten, Philip Höflinger, Philip Höflinger, Philip Höflinger, Jakob Admard, Yvonne Schelling, Yvonne Schelling, Ana Velic, Boris Macek, Stephan Ossowski, Stephan Ossowski, Ludger Schöls, Ludger Schöls, Ludger Schöls   +18 more
doaj   +1 more source

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

The FEBS Journal, EarlyView.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu, Yue Gao, Marcin Luzarowski, Elisabeth Seebach, Thomas Heitkamp, Michael Börsch, Thomas Ruppert, Katharina F. Kubatzky   +7 more
wiley   +1 more source

Pro‐adrenomedullin as an independent predictive biomarker for heart failure in atrial fibrillation and flutter

ESC Heart Failure, Volume 12, Issue 3, Page 1893-1904, June 2025.
Abstract Aims This study aimed to investigate potential biomarkers for predicting incident heart failure (HF) in patients with atrial fibrillation and flutter (AF and AFL), utilizing proteomic data from the UK Biobank Pharma Proteomics Project (UKB‐PPP).
Gaifeng Hu, Xiaodong Peng, Liu He, Yiwei Lai, Nian Liu, Xin Li, Caihua Sang, Jianzeng Dong, Changsheng Ma   +8 more
wiley   +1 more source

Derivation of cable equation by multiscale analysis for a model of myelinated axons [PDF]

arXiv, 2018
The paper concerns the multiscale modeling of a myelinated axon. Taking into account the microstructure with alternating myelinated parts and nodes Ranvier, we derive a nonlinear cable equation describing the potential propagation along the axon.
arxiv  

Optical polarization evolution and transmission in multi-Ranvier-node axonal myelin-sheath waveguides [PDF]

arXiv, 2023
In neuroscience, it is of interest to consider all possible modes of information transfer between neurons in order to fully understand processing in the brain. It has been suggested that photonic communication may be possible along axonal connections, especially through the myelin sheath as a waveguide, due to its high refractive index.
arxiv  

CSF proteomics reveals changes in myelin and synaptic biology after Spectris treatment

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Brain steady‐state gamma oscillations evoked using a non‐invasive medical device (Spectris) have shown potential clinical benefits in patients with mild–moderate Alzheimer's disease (AD), including reduced functional and cognitive decline ...
Mihály Hajós, Kiran Pandey, Annabelle C. Singer, Duc Duong, Sara Bitarafan, Monika Shpokayte, Zach Malchano, Ralph Kern, James J. Lah, Allan I. Levey, Nicholas T. Seyfried   +10 more
doaj   +1 more source