Altered Protein Networks and Cellular Pathways in Severe West Nile Disease in Mice [PDF]
, 2013 Background:The recent West Nile virus (WNV) outbreaks in developed countries, including Europe and the United States, have been associated with significantly higher neuropathology incidence and mortality rate than previously documented.
Almeras, L. (Lionel) +10 more
core +11 more sources
Age-dependent transcriptome and proteome following transection of neonatal spinal cord of Monodelphis domestica (South American grey short-tailed opossum). [PDF]
PLoS ONE, 2014 This study describes a combined transcriptome and proteome analysis of Monodelphis domestica response to spinal cord injury at two different postnatal ages.
Norman R Saunders +13 more
doaj +1 more source
Frontiers in Immunology, 2022 Multiple sclerosis (MS) is an inflammatory demyelinating and degenerative disease of the central nervous system (CNS). Although inflammatory responses are efficiently treated, therapies for progression are scarce and suboptimal, and biomarkers to predict
Maria L. Elkjaer +7 more
doaj +1 more source
Lymph‐based liquid biopsy: Current progress and future potential
Interdisciplinary Medicine, EarlyView.Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu +6 more
wiley +1 more source
Proteomic analysis of phosphoproteins and its application to myelin basic proteins.
SEIBUTSU BUTSURI KAGAKU, 2005 従来タンパク質のリン酸化は, ラジオアイソトープ標識法やウエスタンブロット法を用いて研究されてきたが, 我々は質量分析法による高感度分析法の有効性について基礎的な検討を行った. まずリン酸化部位が既知の標準ペプチドやカゼインを用いて, Post-source decay モードによるMALDI-TOF質量分析を行い, セリンおよびトレオニンリン酸化ペプチド検出における有効性を確認した. しかしチロシンリン酸化ペプチドには, 必ずしも有効ではないこともわかった. 検出感度を上げるために, 市販のリン酸化ペプチドおよびリン酸化タンパク質濃縮キットの使用方法の最適化を行い, 有効性を確認した. さらに我々はこの方法をラットミエリンのミエリン塩基性タンパク質の分析に応用し, リン酸化ペプチドの高感度検出と,
Kyoichi Akiyama +3 more
openaire +2 more sources
What's the Function of Connexin 32 in the Peripheral Nervous System? [PDF]
, 2018 Connexin 32 (Cx32) is a fundamental protein in the peripheral nervous system (PNS) as its mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), the second most common form of hereditary motor and sensory neuropathy and a demyelinating
Bortolozzi, Mario
core +1 more source
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function [PDF]
, 2012 There is still a lack in the molecular comprehension of major depressive disorder (MDD) although this condition affects approximately 10% of the world population.
BK Krueger +62 more
core +2 more sources
ФармакоэкономикаBackground. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect on ...
O. A. Gromova +2 more
doaj +1 more source
Identification of protein networks involved in the disease course of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. [PDF]
PLoS ONE, 2012 A more detailed insight into disease mechanisms of multiple sclerosis (MS) is crucial for the development of new and more effective therapies. MS is a chronic inflammatory autoimmune disease of the central nervous system.
Annelies Vanheel +11 more
doaj +1 more source