Results 271 to 280 of about 44,768 (301)

Novel modulation on myeloid-derived suppressor cells (MDSCs) by methionine encephalin (MENK)

International Immunopharmacology, 2019
The purpose of this study was to identify the modulatory effect of MENK on MDSCs and to investigate the relationship between this modulation and the expression of opioid receptors. Our results showed that MENK could inhibit the proliferation of MDSCs from both marine bone marrow and spleen. MENK also could promote the expression of opioid receptors MOR
Jin, Geng, Ye, Yuan, Xue, Jiao, Ruizhe, Wang, Ning, Liu, Hao, Chen, Noreen, Griffin, Fengping, Shan   +7 more
openaire   +2 more sources

Regulation of Myeloid Derived Suppressor Cell (MDSC) dynamics by T regulatory cells

The Journal of Immunology, 2017
Abstract Multiple sclerosis is an inflammatory demyelinating autoimmune disorder affecting the central nervous system whose severity is reduced using immune suppressive drugs. Therapeutic intervention with interferon-b reduces disease exacerbations and delays relapses.
Shalini Tanwar, Ethan M Shevach
openaire   +1 more source

Myeloid derived suppressor cells(MDSCs) emergence from distinct splenic precursors (162.28)

The Journal of Immunology, 2012
Abstract Myeloid derived suppressor cells(MDSCs) are a heterogenous population of immature myeloid cells, which accumulate in various pathological conditions, especially in tumor. In mice, MDSCs are characterized by the co-expression of Gr1 and CD11b molecules, and these cells could be classified into two subsets, CD11b+Ly6G+Ly6Clow ...
Young-Jun Park, Boyeong Song, Yun-Sun Kim, Eun-Kyung Kim, Jung-Mi Lee, Ga-Eun Lee, Jae-Ouk Kim, Yeon-Jeong Kim, Woo-Sung Chang, Chang-Yuil Kang   +9 more
openaire   +1 more source

Abstract LB-192: Phenotyping human myeloid derived suppressor cells (MDSC) subsets

Cancer Research, 2017
Abstract MDSCs are heterogeneous occurring at varying stages of commitment and differentiation. They increase in cancer and other patients with inflammatory diseases and may best be defined based on their ability to suppress T and B cell responses.
James E. Talmadge, Holly Britton, Alicia Dafferner, Phyllis Warkentin, Kathryn Cole   +4 more
openaire   +1 more source

Myeloid-Derived Suppressor Cells (MDSCs) in Aged Mice: Focus on Inflammation

2018
Fil: Castell, Sofía Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba.
Pistoresi, Maria Cristina, Harman, María Florencia, Castell, Sofía Daiana   +2 more
openaire   +2 more sources

Detection of Circulating and Tissue Myeloid-Derived Suppressor Cells (MDSC) by Flow Cytometry

2021
Flow cytometry allows the multiparameter analysis of heterogeneous cell populations and is an essential tool for detecting and characterizing different cell populations from peripheral blood and dissociated tissues. Myeloid-derived suppressor cells (MDSC) are a heterogeneous and plastic group of myeloid precursors with immune-suppressive capacity ...
openaire   +2 more sources

Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function

Journal of Leukocyte Biology, 2016
Abstract Myeloid-derived suppressor cells (MDSCs) are immature cells that do not differentiate into mature myeloid cells. Two major populations of PMN-MDSCs (Ly6GhighLy6ClowGr1highCD11b+) and MO-MDSCs (Ly6G−Ly6ChighGr-1intCD11b+) have an immune suppressive function.
Sorim, Nam, Kyeongah, Kang, Jae Seon, Cha, Jung Woo, Kim, Hee Gu, Lee, Yonghwan, Kim, Young, Yang, Myeong-Sok, Lee, Jong-Seok, Lim   +8 more
openaire   +2 more sources

Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC)

Cancer Immunology, Immunotherapy, 2012
Immune suppressive myeloid-derived suppressor cells (MDSC) are present in most cancer patients where they inhibit innate anti-tumor immunity and are a significant obstacle to cancer immunotherapy. Inflammation is a known inducer of Gr1(+)CD11b(+) MDSC; however, the factors/conditions that regulate MDSC survival and half-life have not been identified ...
Suzanne, Ostrand-Rosenberg, Pratima, Sinha, Olesya, Chornoguz, Christopher, Ecker   +3 more
openaire   +2 more sources

Myeloid derived suppressor cells (MDSCS) reduce the manufacturing feasibilty of gene modified T cells.

Cytotherapy, 2019
Background & Aim With the goal of improving consistency and success of manufacturing (MFG), we analyzed the composition of apheresis products collected from patients (pts) enrolled in clinical trials of engineered T cell immunotherapies. We previously reported in a small cohort of NHL pts, that T cell cultures manufactured from fresh APH of ...
M. Gohil, A. Dai, S. Mackey, D. Negorev, N.A. Hennesy, M. O'Rourke, A. Lamontagne, D. Holland, R.M. Leskowitz, J. Xu, M. Ozerova, J.S. McKee, E. Pequignot, D. Siegel, S. Schuster, J. Svoboda, A. Garfall, A. Cohen, E. Stadtmauer, W. Gladney, B.L. Levine, J.A. Fraietta, M.M. Davis   +22 more
openaire   +1 more source

Characterization of myeloid-derived suppressor cells (MDSCs) in endometrial cancer (2292)

Gynecologic Oncology, 2023
Tiffany Jones, Rebecca Stone, Tian-Li Wang, Ie-Ming Shih, Yu-Liang Yeh   +4 more
openaire   +1 more source