Results 51 to 60 of about 44,768 (301)

Gene expression profiling of human fibrocytic myeloid-derived suppressor cells (f-MDSCs)

Genomics Data, 2014
Myeloid-derived suppressor cells (MDSCs) have been shown to control self-reactive and anti-graft effector T-cells in autoimmunity and transplantation, but their therapeutic use is limited by their scarce availability in the peripheral blood of tumor-free donors.
MAZZA, Emilia Maria Cristina, Zoso, Alessia, Mandruzzato, Susanna, Bronte, Vincenzo, Serafini, Paolo, Inverardi, Luca, BICCIATO, Silvio   +6 more
openaire   +5 more sources

Myeloid-derived suppressor cells in non-neoplastic inflamed organs

Inflammation and Regeneration, 2018
Background Myeloid-derived suppressor cells (MDSCs) are a highly heterogeneous population of immature myeloid cells with immunosuppressive function. Although their function in tumor-bearing conditions is well studied, less is known about the role of ...
Sho Sendo, Jun Saegusa, Akio Morinobu
doaj   +1 more source

Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]

, 2016
Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D., Graham, Laura, Idowu, Michael O., Keim, Rebecca, Manjili, Masoud H., Payne, Kyle K., Toor, Amir A., Wan, Wen, Wang, Xiang-Yang   +8 more
core   +2 more sources

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function [PDF]

, 2010
Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation.
Angus, Badolato, Bernard, Betz, Bozic, Buras, Byl, Cheng, Cheng, Christenson, Christian Trautwein, Delano, Ernst, Fisher, Foreman, Frank Tacke, Gabay, Gabrilovich, Haile, Hoechst, Hotchkiss, Hotchkiss, J. Magarian Blander, Kim, Klein, Kopf, Leif E. Sander, Luchtefeld, Matuschak, Medzhitov, Michael Müller, Movahedi, Murakami, Nagaraj, Naiara Beraza, Nefedova, Parrish, Rebouissou, Reinhold P. Linke, Riedemann, Ritchie, Rittirsch, Rittirsch, Sara Dutton Sackett, Shah, Sinha, Streetz, Tebbutt, Uta Dierssen, Wuestefeld, Yang, Young, Zhu, Zouki   +53 more
core   +4 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The predictive value of peripheral blood monocytic myeloid-derived suppressor cells for survival and immunotherapy responses in tumor patients

BMC Immunology
Background and objectives The identification of affordable and easily accessible indicators to predict overall survival is important for tumor immunotherapy.
Wanying Sheng, Yan Ding, Yuting Su, Jing Hu, Lu Wang, Minjie Guo, Xiao Yuan, Deqiang Wang, Chunhua Dai, Xu Wang   +9 more
doaj   +1 more source

Apolipoprotein A-I Mimetic Peptide L-4F Suppresses Granulocytic-Myeloid-Derived Suppressor Cells in Mouse Pancreatic Cancer

Frontiers in Pharmacology, 2020
L-4F is an apolipoprotein A-I (ApoA-I) mimetic peptide, it was engineered to imitate the anti-inflammatory and anti-oxidative activity of ApoA-I. In this paper, H7 cell was used to construct a mouse model of pancreatic cancer in situ, and the mice were ...
Meiyu Peng, Qi Zhang, Yanqing Liu, Xiangdong Guo, Jiyu Ju, Lingzhi Xu, Yuanyuan Gao, Daquan Chen, Dongzhen Mu, Rongxin Zhang   +9 more
doaj   +1 more source

Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer

Cells, 2021
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity. They also directly stimulate tumor cell proliferation, metastasis, and angiogenesis.
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura   +2 more
doaj   +1 more source

Re-polarizing Myeloid-derived Suppressor Cells (MDSCs) with Cationic Polymers for Cancer Immunotherapy. [PDF]

Sci Rep, 2016
AbstractOur evolving understandings of cell-material interactions provide insights for using polymers to modulate cell behaviour that may lead to therapeutic applications. It is known that in certain cancers, myeloid-derived suppressor cells (MDSCs) play vital roles in promoting tumour progression, chiefly because of their ‘alternatively activated’ (or
He W, Liang P, Guo G, Huang Z, Niu Y, Dong L, Wang C, Zhang J.   +7 more
europepmc   +3 more sources

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation [PDF]

, 2015
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation.
Agostinis, C, Botto, M, Bulla, R, Durigutto, P, Guarnotta, C, Ling, GS, Rami, D, Tedesco, F, Tripodo, C, Zorzet, S   +9 more
core   +3 more sources