Results 61 to 70 of about 44,768 (301)
Advanced Science, EarlyView.ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu +10 more
wiley +1 more source
Nature Communications, 2017 Myeloid-derived suppressor cells (MDSCs) promote tumor immune escape. Here, the authors show that in hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells leading to elevated extracellular 5′-AMP, which in turn promote the ...
David Kung-Chun Chiu +11 more
doaj +1 more source
Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer
Life Science Alliance, 2020 This study shows that immunosuppressive primary breast cancer patient–derived G-MDSCs (PMN-MDSCs) are neutrophils at a range of maturations stages, and provides in vivo evidence for that human G-MDSCs also promote tumor growth and myeloid immune cell ...
Meliha Mehmeti-Ajradini +20 more
doaj +1 more source
In Brief: Myeloid-derived suppressor cells in cancer [PDF]
, 2017 The role of myeloid-derived suppressor cells (MDSCs) in cancer development has become clear over recent years, and MDSC targeting is an emerging opportunity for enhancing the effectiveness of current anticancer therapies.
Bronte +8 more
core +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer
Mediators of Inflammation, 2015 Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived ...
Hiroshi Katoh, Masahiko Watanabe
doaj +1 more source
Myeloid-derived suppressor cells in gliomas
Contemporary Oncology, 2016 Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid progenitors and precursors at different stages of differentiation into granulocytes, macrophages, and dendritic cells.
Anna Gieryng, Bozena Kaminska
doaj +1 more source
Activation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal(-/-) mice [PDF]
, 2014 Inflammation critically contributes to cancer metastasis, in which myeloid-derived suppressor cells (MDSCs) are an important participant. Although MDSCs are known to suppress immune surveillance, their roles in directly stimulating cancer cell ...
Ding, Xinchun +4 more
core +2 more sources
Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth [PDF]
OncoImmunology, 2012 Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population.
Fujimura, Taku +2 more
openaire +2 more sources
Journal of Clinical Immunology, 2022 AbstractCommon variable immunodeficiency disorders (CVID), the most common primary immune deficiency, includes heterogeneous syndromes characterized by hypogammaglobulinemia and impaired antibody responses. CVID patients frequently suffer from recurrent infections and inflammatory conditions.
Simón-Fuentes, Miriam +7 more
openaire +3 more sources