Results 41 to 50 of about 626,152 (307)

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

Frontiers in Immunology, 2018
Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages ...
Robin Maximilian Awad, Yannick De Vlaeminck, Johannes Maebe, Cleo Goyvaerts, Karine Breckpot   +4 more
doaj   +1 more source

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study [PDF]

, 2016
There is an increasing interest for monitoring circulating myeloid-derived suppressor cells (MDSCs) in cancer patients, but there are also divergences in their phenotypic definition.
Brandau, Sven, Britten, Cedrik M, Bronte, Vincenzo, Damuzzo, Vera, Gouttefangeas, C\ue9cile, Mandruzzato, Susanna, Maurer, Dominik, Ottensmeier, Christian, van der Burg, Sjoerd H, Walter, Steffen, Welters, Marij J. P   +10 more
core   +2 more sources

Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]

, 2014
Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam, Coughlan, Karen, Gibbs, Bernhard F., Lall, Gurprit S., Lall, Harjinder S., Sumbayev, Vadim V.   +5 more
core   +1 more source

Characteristics of Tip-DCs and MDSCs and their potential role in leishmaniasis

Frontiers in Microbiology, 2012
Since the first description of dendritic cells (DCs) by Ralph Marvin Steinman and Zanvil Alexander Cohn in 1973, the myeloid lineage of leukocytes was investigated intensively.
Maximilian eSchmid, Anja Kathrin Wege, Uwe eRitter   +2 more
doaj   +1 more source

Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

OncoImmunology, 2017
The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting.
Xiaowei Chen, Yoshihiro Takemoto, Huan Deng, Moritz Middelhoff, Richard A. Friedman, Timothy H. Chu, Michael J. Churchill, Yan Ma, Karan K. Nagar, Yagnesh H. Tailor, Siddhartha Mukherjee, Timothy C. Wang   +11 more
doaj   +1 more source

Targeting Metabolic Pathways of Myeloid Cells Improves Cancer Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Tumor-infiltrating myeloid cells are a prominent pro-tumorigenic immune cell population that limit host anti-tumor immunity and present a significant obstacle for many cancer immunotherapies.
Jianying Li, Chelsea Bolyard, Gang Xin, Gang Xin, Zihai Li, Zihai Li   +5 more
doaj   +1 more source

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer [PDF]

, 2016
Tumor–stroma interactions contribute to tumorigenesis. Tumor cells can educate the stroma at primary and distant sites to facilitate the recruitment of heterogeneous populations of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs).
Ali Zamani, Andrea Wang-Gillam, Aude-Hélène Capietto, Barcellos-Hoff, Biancamaria Ricci, Bindea, Capietto, David B. Bumpass, David G. DeNardo, Fowler, Gabitass, Gabrilovich, Gabrilovich, Galon, Hamanishi, Katherine Weilbaecher, Li, Liu, Lucia D’Amico, MacDonald, Mace, Mahmoud, Melissa Meyer, Mitchem, Mundy-Bosse, Pinzone, Porembka, Roberta Faccio, Räsänen, Sahil Mahajan, Schreiber, Sheila A. Stewart, Tian, Trikha, Weilbaecher, Xinming Su, Yaccoby, Yamabuki, Yang, Zhang, Zhang, Zheng, Zhengfeng Yang, Zhu   +43 more
core   +2 more sources

Peripherally derived myeloid cells induce disease-dependent phenotypic changes in microglia

Frontiers in Cellular Neuroscience, 2023
In central nervous system (CNS) injury and disease, peripherally derived myeloid cells infiltrate the CNS parenchyma and interact with resident cells, propagating the neuroinflammatory response.
Estrid Thougaard, Estrid Thougaard, Brianna Carney, Agnieszka Wlodarczyk, Agnieszka Wlodarczyk, Roberta Brambilla, Roberta Brambilla, Roberta Brambilla, Kate Lykke Lambertsen, Kate Lykke Lambertsen, Kate Lykke Lambertsen   +10 more
doaj   +1 more source

Myeloid Cells in Asthma

Microbiology Spectrum, 2017
ABSTRACTAsthma is a heterogeneous chronic inflammatory disorder of the airways, and not surprisingly, many myeloid cells play a crucial role in pathogenesis. Antigen-presenting dendritic cells are the first to recognize the allergens, pollutants, and viruses that are implicated in asthma pathogenesis, and subsequently initiate the adaptive immune ...
Bart N, Lambrecht, Emma K, Persson, Hamida, Hammad   +2 more
openaire   +2 more sources

Type I Interferon Activates PD-1 Expression through Activation of the STAT1-IRF2 Pathway in Myeloid Cells

Cells
PD-1 (Programmed cell death protein 1) regulates the metabolic reprogramming of myeloid-derived suppressor cells and myeloid cell differentiation, as well as the type I interferon (IFN-I) signaling pathway in myeloid cells in the tumor microenvironment ...
Liyan Liang, Yingcui Yang, Kaidi Deng, Yanmin Wu, Yan Li, Liya Bai, Yinsong Wang, Chunwan Lu   +7 more
doaj   +1 more source