Results 41 to 50 of about 126,969 (246)

Tuning the Tumor Myeloid Microenvironment to Fight Cancer

Frontiers in Immunology, 2019
The tumor microenvironment (TME) of diverse cancer types is often characterized by high levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and granulocytes.
Nadine S. Jahchan, Adriana M. Mujal, Joshua L. Pollack, Mikhail Binnewies, Venkataraman Sriram, Leonard Reyno, Matthew F. Krummel, Matthew F. Krummel   +7 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Adoptive Transfer of Monocytes Sorted from Bone Marrow

Bio-Protocol, 2019
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages (TAMs), M1-like TAMs
Damya Laoui, Eva Overmeire, Chloé Abels, Jiri Keirsse, Jo Ginderachter   +4 more
doaj   +1 more source

Development of endocytosis, degradative activity, and antigen processing capacity during GM-CSF driven differentiation of murine bone marrow. [PDF]

PLoS ONE, 2018
Dendritic cells (DC) are sentinels of the immune system, alerting and enlisting T cells to clear pathogenic threats. As such, numerous studies have demonstrated their effective uptake and proteolytic activities coupled with antigen processing and ...
Adesola C Olatunde, Laura P Abell, Ashley E Landuyt, Elizabeth Hiltbold Schwartz   +3 more
doaj   +1 more source

Culture of myeloid dendritic cells from bone marrow precursors [PDF]

Journal of Visualized Experiments, 2008
Myeloid dendritic cells (DCs) are frequently used to study the interactions between innate and adaptive immune mechanisms and the early response to infection. Because these are the most potent antigen presenting cells, DCs are being increasingly used as a vaccine vector to study the induction of antigen-specific immune responses.
Jeanette, Boudreau, Sandeep, Koshy, Derek, Cummings, Yonghong, Wan   +3 more
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells

Frontiers in Immunology, 2018
The importance of myeloid cells in HIV transmission in the female genital tract is uncertain. Because it is difficult to study the early events in HIV transmission in humans, most of our knowledge is based on animal models of SIV infection in Rhesus ...
Radiana T. Trifonova, Brooke Bollman, Natasha S. Barteneva, Judy Lieberman   +3 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection

Retrovirology, 2012
Background HIV-1 infection is associated with profound dysfunction of myeloid dendritic cells, for reasons that remain ill-defined. Soluble HLA class I molecules can have important inhibitory effects on T cells and NK cells, but may also contribute to ...
Huang Jinghe, Al-Mozaini Maha, Rogich Jerome, Carrington Mary F, Seiss Katherine, Pereyra Florencia, Lichterfeld Mathias, Yu Xu G   +7 more
doaj   +1 more source

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry

STAR Protocols, 2020
Summary: Myeloid cells, including dendritic cells (DCs), granulocytes, monocytes, monocyte-derived cells and macrophages, are important players in the immune response, but their identification is not as clear as lymphocytes, especially in tissues.
Zhaoyuan Liu, Yaqi Gu, Amanda Shin, Shuangyan Zhang, Florent Ginhoux   +4 more
doaj   +1 more source