Results 51 to 60 of about 4,990,718 (300)
Retrovirology, 2012 Background HIV-1 infection is associated with profound dysfunction of myeloid dendritic cells, for reasons that remain ill-defined. Soluble HLA class I molecules can have important inhibitory effects on T cells and NK cells, but may also contribute to ...
Huang Jinghe +7 more
doaj +1 more source
Development of endocytosis, degradative activity, and antigen processing capacity during GM-CSF driven differentiation of murine bone marrow. [PDF]
PLoS ONE, 2018 Dendritic cells (DC) are sentinels of the immune system, alerting and enlisting T cells to clear pathogenic threats. As such, numerous studies have demonstrated their effective uptake and proteolytic activities coupled with antigen processing and ...
Adesola C Olatunde +3 more
doaj +1 more source
Plasmacytoid Dendritic Cell Infiltration in Acute Myeloid Leukemia.
Cancer management and research, 2020 Increasing evidence has demonstrated that plasmacytoid dendritic cells (PDCs) in the tumor microenvironment (TME) play an important role in tumorigenesis and progression. PDC infiltration has been found in certain malignancies such as classic Hodgkin's lymphoma and chronic myelomonocytic leukemia.
Zhu,Lidan +13 more
openaire +4 more sources
Myeloid dendritic cells in inclusion‐body myositis and polymyositis [PDF]
Muscle & Nerve, 2006 AbstractDendritic cells (DCs), immune system cells central to the development of immunity, have not previously been reported in muscle in inclusion‐body myositis (IBM). We performed immunohistochemical studies on muscle biopsy specimens from 50 patients using monoclonal antibodies that distinguish two classes of DCs, myeloid DC and plasmacytoid DC.
Steven A, Greenberg +3 more
openaire +2 more sources
A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections [PDF]
, 2007 Mycobacterium tuberculosis (M. tuberculosis) is responsible for 2 million deaths annually. In recent years co-infection with HIV and drug-resistant strains has led to the increase in clinical cases of tuberculosis.
Krishnan, Nitya
core
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells
Frontiers in Immunology, 2018 The importance of myeloid cells in HIV transmission in the female genital tract is uncertain. Because it is difficult to study the early events in HIV transmission in humans, most of our knowledge is based on animal models of SIV infection in Rhesus ...
Radiana T. Trifonova +3 more
doaj +1 more source
Positive and negative regulation of the myeloid dendritic cell lineage [PDF]
Journal of Leukocyte Biology, 1999 Abstract Recent advances have revealed that dendritic cells (DCs) are not a single cell type, but a system of cells that are phenotypically and functionally diverse. DC subtypes stemming from the myeloid and lymphoid lineages promote a diversity of immune responses ranging from the stimulation of naive T and B cell responses to the down ...
openaire +2 more sources
Characterization of Myeloid and Plasmacytoid Dendritic Cells in Human Lung [PDF]
The Journal of Immunology, 2006 Abstract Dendritic cells (DCs) are bone marrow-derived mononuclear cells that play a central role in the initiation of immune responses. Because human lung DCs have been incompletely characterized, we enumerated and phenotyped mononuclear cell populations from excess lung tissue obtained at surgery.
Barbara J, Masten +7 more
openaire +2 more sources
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source