Results 31 to 40 of about 132,354 (264)

Myeloid dendritic cells in inclusion‐body myositis and polymyositis [PDF]

Muscle & Nerve, 2006
AbstractDendritic cells (DCs), immune system cells central to the development of immunity, have not previously been reported in muscle in inclusion‐body myositis (IBM). We performed immunohistochemical studies on muscle biopsy specimens from 50 patients using monoclonal antibodies that distinguish two classes of DCs, myeloid DC and plasmacytoid DC.
Steven A, Greenberg, Geraldine S, Pinkus, Anthony A, Amato, Jack L, Pinkus   +3 more
openaire   +2 more sources

Exploration of the Causal Roles of Immune Cells and Inflammatory Proteins in Aortic Dissection via Mendelian Randomization

Cardiovascular Innovations and Applications
Aortic dissection is a life-threatening condition with complex immunological underpinnings. This study was aimed at exploring the causal relationships among immune cells, inflammatory proteins, and aortic dissection, through Mendelian randomization ...
Yueye Chen, Ye Chen, Jingyu Zhu, Jamol Uzokov, Yuemeng Li, Jingming Feng, Ayumi Aurea Miyakawa, Kun Liu, Yanshuo Han   +8 more
doaj   +1 more source

Adoptive Transfer of Monocytes Sorted from Bone Marrow

Bio-Protocol, 2019
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages (TAMs), M1-like TAMs
Damya Laoui, Eva Overmeire, Chloé Abels, Jiri Keirsse, Jo Ginderachter   +4 more
doaj   +1 more source

Characterization of Myeloid and Plasmacytoid Dendritic Cells in Human Lung [PDF]

The Journal of Immunology, 2006
Abstract Dendritic cells (DCs) are bone marrow-derived mononuclear cells that play a central role in the initiation of immune responses. Because human lung DCs have been incompletely characterized, we enumerated and phenotyped mononuclear cell populations from excess lung tissue obtained at surgery.
Barbara J, Masten, Gwyneth K, Olson, Christy A, Tarleton, Chad, Rund, Mark, Schuyler, Reza, Mehran, Tereassa, Archibeque, Mary F, Lipscomb   +7 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Tuning the Tumor Myeloid Microenvironment to Fight Cancer

Frontiers in Immunology, 2019
The tumor microenvironment (TME) of diverse cancer types is often characterized by high levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and granulocytes.
Nadine S. Jahchan, Adriana M. Mujal, Joshua L. Pollack, Mikhail Binnewies, Venkataraman Sriram, Leonard Reyno, Matthew F. Krummel, Matthew F. Krummel   +7 more
doaj   +1 more source

Development of endocytosis, degradative activity, and antigen processing capacity during GM-CSF driven differentiation of murine bone marrow. [PDF]

PLoS ONE, 2018
Dendritic cells (DC) are sentinels of the immune system, alerting and enlisting T cells to clear pathogenic threats. As such, numerous studies have demonstrated their effective uptake and proteolytic activities coupled with antigen processing and ...
Adesola C Olatunde, Laura P Abell, Ashley E Landuyt, Elizabeth Hiltbold Schwartz   +3 more
doaj   +1 more source

Blood myeloid cells differentiate to lung resident cells and respond to pathogen stimuli in a 3D human tissue-engineered lung model

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Respiratory infections remain a leading global health concern. Models that recapitulate the cellular complexity of the lower airway of humans will provide important information about how the immune response reflects the interactions between
Mandi M. Roe, Taylor Do, Sean Turner, Allison M. Jevitt, Magdalena Chlebicz, Karley White, Antonius G. P. Oomens, Susannah Rankin, Susan Kovats, Susan Kovats, Heather Gappa-Fahlenkamp   +10 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection

Retrovirology, 2012
Background HIV-1 infection is associated with profound dysfunction of myeloid dendritic cells, for reasons that remain ill-defined. Soluble HLA class I molecules can have important inhibitory effects on T cells and NK cells, but may also contribute to ...
Huang Jinghe, Al-Mozaini Maha, Rogich Jerome, Carrington Mary F, Seiss Katherine, Pereyra Florencia, Lichterfeld Mathias, Yu Xu G   +7 more
doaj   +1 more source