Results 11 to 20 of about 132,354 (264)
Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin [PDF]
Proceedings of the National Academy of Sciences, 1997 Dendritic cells (DC) have been thought to represent a family of closely related cells with similar functions and developmental pathways. The best-characterized precursors are the epidermal Langerhans cells, which migrate to lymphoid organs and become activated DC in response to inflammatory stimuli.
J, Olweus +6 more
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Dendritic Cell-Based Immunotherapy for Myeloid Leukemias [PDF]
Frontiers in Immunology, 2013 Acute and chronic myeloid leukemia (AML, CML) are hematologic malignancies arising from oncogene-transformed hematopoietic stem/progenitor cells known as leukemia stem cells (LSCs). LSCs are selectively resistant to various forms of therapy including irradiation or cytotoxic drugs.
Christian Martijn Schürch +4 more
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Interaction of Rotavirus with Human Myeloid Dendritic Cells [PDF]
Journal of Virology, 2005 ABSTRACTWe have previously shown that very few rotavirus (RV)-specific T cells that secrete gamma interferon circulate in recently infected and seropositive adults and children. Here, we have studied the interaction of RV with myeloid immature (IDC) and mature dendritic cells (MDC) in vitro.
Carlos F, Narváez +2 more
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Myeloid dendritic cells in HIV-1 infection [PDF]
Current Opinion in HIV and AIDS, 2011 Myeloid dendritic cells (mDCs) are pivotal players in HIV-1 infection. They promote transmission and spread and at the same time are critical for recognizing HIV-1 and initiating immune responses to fight infection. Notably, their immunostimulatory capabilities can be harnessed to design better HIV-1 vaccines. In this review, advances in these areas of
Nina, Derby +2 more
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Increased Blood Myeloid Dendritic Cells and Dendritic Cell-Poietins in Langerhans Cell Histiocytosis [PDF]
The Journal of Immunology, 2005 Abstract Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is a reactive proliferative disease of unknown pathogenesis. Current therapies are based on nonspecific immunosuppression. Because multiple APCs, including Langerhans cells and macrophages, are involved in the lesion formation, we surmised that LCH is a ...
Alexandre, Rolland +6 more
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Dendritic Cell-Based Immunotherapy of Acute Myeloid Leukemia [PDF]
Journal of Clinical Medicine, 2019 Acute myeloid leukemia (AML) is a type of blood cancer characterized by the uncontrolled clonal proliferation of myeloid hematopoietic progenitor cells in the bone marrow. The outcome of AML is poor, with five-year overall survival rates of less than 10% for the predominant group of patients older than 65 years.
Heleen H. Van Acker +9 more
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Myeloid blood dendritic cells and monocyte-derived dendritic cells differ in their endocytosing capability [PDF]
Human Immunology, 2012 Human dendritic cells (DCs) constitute a heterogeneous population of antigen-presenting cells characterized by a unique capacity to stimulate naïve T cells. The functions of DCs depend on the particular subset and in this study we compare two types of myeloid DCs: freshly isolated blood mDCs and in vitro generated monocyte-derived DCs (MoDCs), in their
Andersson, Linda +3 more
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Negative impact of proteinuria on circulating myeloid dendritic cells. [PDF]
Clin Exp Nephrol, 2019 A decrease in absolute numbers (abs.) of circulating dendritic cells (DCs) and recruitment into target organs has been reported, but whether the level of proteinuria associates with circulating DC abs. has not been clarified.We conducted a cross-sectional study of 210 patients with kidney disease aged 21-96 years who were admitted to our hospital for ...
Ikeda M +10 more
europepmc +4 more sources
Dendritic cells and myeloid leukaemias: plasticity and commitment in cell differentiation [PDF]
British Journal of Haematology, 2007 SummaryDendritic cells (DCs) are key antigen‐presenting cells (APCs), which link innate and adaptive immunity, ultimately activating antigen‐specific T cells. This review examines the relationship between the acute and chronic myeloid leukaemias and cells with DC properties.
Jane, Rasaiyaah +4 more
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Virulence, 2012 Dendritic cells (DC) are a heterogeneous population of innate immune cells that are fundamental to initiating responses against invading pathogens and regulating immune responses. Myeloid DC (mDC) act as a bridge between the innate and adaptive immune response during virus infections but their role in immunity to human immunodeficiency virus (HIV ...
Wonderlich, Elizabeth R. +1 more
openaire +2 more sources