Results 41 to 50 of about 4,990,718 (300)

Restricted Access to Myeloid Cells Explained

Viruses, 2011
The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular
Vicente Planelles
doaj   +1 more source

Distribution of Myeloid and Plasmacytoid Dendritic Cell Subpopulations in Peripheral Blood of Hyperprolactinemic Women

Iranian Journal of Allergy, Asthma and Immunology, 2021
Dendritic cells (DCs) play key roles in regulating the immune response using the specialized function of processing and presenting antigens. Prolactin (PRL), a hormone produced by the pituitary gland, participates in DC maturation and function.
Fatemeh Raeesi Nejad, Mohammad Mahdi Mohammadi, Mojgan Sanjari, Reza Malkpour Afshar, Elham Jafari   +4 more
doaj   +1 more source

The role of DC-SIGN as a trans-receptor in infection by MERS-CoV

Frontiers in Cellular and Infection Microbiology, 2023
DC-SIGN is a C-type lectin expressed in myeloid cells such as immature dendritic cells and macrophages. Through glycan recognition in viral envelope glycoproteins, DC-SIGN has been shown to act as a receptor for a number of viral agents such as HIV ...
Nuria Labiod, Joanna Luczkowiak, María M. Tapia, Fátima Lasala, Rafael Delgado, Rafael Delgado, Rafael Delgado   +6 more
doaj   +1 more source

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection [PDF]

, 2013
Persistent production of type I interferon (IFN) by activated plasmacytoid dendritic cells (pDC) is a leading model to explain chronic immune activation in human immunodeficiency virus (HIV) infection but direct evidence for this is lacking.
Simon C Watkins, Normolle, D, Kader, M, Elizabeth R Wonderlich, Guiducci, C, Smith, Amanda P., Watkins, SC, Amanda P. Smith (437248), Normolle, Daniel, Watkins Simon C., Franck J. Barrat (437251), Smith Amanda P., Simon M Barratt-Boyes, Daniel Normolle, Daniel Normolle (437250), Barrat Franck J., Simon M. Barratt-Boyes (264203), Normolle Daniel, Wonderlich Elizabeth R., Franck J Barrat, Barratt-Boyes Simon M., Guiducci, Cristiana, Barrat, Franck J., Kader, Muhamuda, Guiducci Cristiana, Wonderlich, ER, Cristiana Guiducci, Barrat, FJ, Watkins, Simon C., Amanda P Smith, Barratt-Boyes, SM, Muhamuda Kader, Smith, AP, Wonderlich, Elizabeth R., Cristiana Guiducci (437249), Simon C. Watkins (39900), Barratt-Boyes, Simon M., Muhamuda Kader (437247), Elizabeth R. Wonderlich (270792), Kader Muhamuda   +39 more
core   +2 more sources

Exploration of the Causal Roles of Immune Cells and Inflammatory Proteins in Aortic Dissection via Mendelian Randomization

Cardiovascular Innovations and Applications
Aortic dissection is a life-threatening condition with complex immunological underpinnings. This study was aimed at exploring the causal relationships among immune cells, inflammatory proteins, and aortic dissection, through Mendelian randomization ...
Yueye Chen, Ye Chen, Jingyu Zhu, Jamol Uzokov, Yuemeng Li, Jingming Feng, Ayumi Aurea Miyakawa, Kun Liu, Yanshuo Han   +8 more
doaj   +1 more source

Adoptive Transfer of Monocytes Sorted from Bone Marrow

Bio-Protocol, 2019
Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages (TAMs), M1-like TAMs
Damya Laoui, Eva Overmeire, Chloé Abels, Jiri Keirsse, Jo Ginderachter   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Tuning the Tumor Myeloid Microenvironment to Fight Cancer

Frontiers in Immunology, 2019
The tumor microenvironment (TME) of diverse cancer types is often characterized by high levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and granulocytes.
Nadine S. Jahchan, Adriana M. Mujal, Joshua L. Pollack, Mikhail Binnewies, Venkataraman Sriram, Leonard Reyno, Matthew F. Krummel, Matthew F. Krummel   +7 more
doaj   +1 more source

Blood myeloid cells differentiate to lung resident cells and respond to pathogen stimuli in a 3D human tissue-engineered lung model

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Respiratory infections remain a leading global health concern. Models that recapitulate the cellular complexity of the lower airway of humans will provide important information about how the immune response reflects the interactions between
Mandi M. Roe, Taylor Do, Sean Turner, Allison M. Jevitt, Magdalena Chlebicz, Karley White, Antonius G. P. Oomens, Susannah Rankin, Susan Kovats, Susan Kovats, Heather Gappa-Fahlenkamp   +10 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source