Results 41 to 50 of about 132,354 (264)
Myeloid and Plasmacytoid Dendritic Cells and Cancer – New Insights [PDF]
Open Access Macedonian Journal of Medical Sciences, 2019 Dendritic cells (DCs) use effective mechanisms to combat antigens and to bring about adaptive immune responses through their ability to stimulate nӓive T cells. At present, four major cell types are categorised as DCs: Classical or conventional (cDCs), Plasmacytoid (pDCs), Langerhans cells (LCs), and monocyte-derived DCs (Mo-DCs). It was suggested that
Maya Gulubova +5 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells
Frontiers in Immunology, 2018 The importance of myeloid cells in HIV transmission in the female genital tract is uncertain. Because it is difficult to study the early events in HIV transmission in humans, most of our knowledge is based on animal models of SIV infection in Rhesus ...
Radiana T. Trifonova +3 more
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Plasmacytoid Dendritic Cell Infiltration in Acute Myeloid Leukemia.
Cancer management and research, 2020 Increasing evidence has demonstrated that plasmacytoid dendritic cells (PDCs) in the tumor microenvironment (TME) play an important role in tumorigenesis and progression. PDC infiltration has been found in certain malignancies such as classic Hodgkin's lymphoma and chronic myelomonocytic leukemia.
Zhu,Lidan +13 more
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Renal FailureObjective Previous observational studies have indicated associations between various immune cells and diabetic nephropathy (DN). However, the causality remains unclear. We aimed to further evaluate the causal association between immune cells and DN using
Siyuan Song, Yuqing Sun, Jiangyi Yu
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Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
Stem Cells International, 2011 While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined.
Helen C. O'Neill +6 more
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Illuminating the Role of Vpr in HIV Infection of Myeloid Cells
Frontiers in Immunology, 2019 Vpr is a 14 kDa accessory protein conserved amongst extant primate lentiviruses that is required for virus replication in vivo. Although many functions have been attributed to Vpr, its primary role, and the function under selective pressure in vivo ...
Sarah Beth Nodder, Suryaram Gummuluru
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Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry
STAR Protocols, 2020 Summary: Myeloid cells, including dendritic cells (DCs), granulocytes, monocytes, monocyte-derived cells and macrophages, are important players in the immune response, but their identification is not as clear as lymphocytes, especially in tissues.
Zhaoyuan Liu +4 more
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HCMV Displays a Unique Transcriptome of Immunomodulatory Genes in Primary Monocyte-Derived Cell Types. [PDF]
PLoS ONE, 2016 Human cytomegalovirus (HCMV) is a betaherpesvirus which rarely presents problems in healthy individuals, yet may result in severe morbidity in immunocompromised patients and in immune-naïve neonates.
Ellen Van Damme +5 more
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